| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Perceptive Advisors Joseph Edelman | 7,471,798 | $121,342 | +63% | 1.76% |
| 2. | VenBio Select Advisor Kurt Von Emster | 7,100,000 | $115,304 | +11% | 1.81% |
| 3. | Vivo Capital Albert Cha And Frank Kung | 5,966,527 | $96,896 | 4.35% | |
| 4. | Yiheng Capital Jonathan Guo | 5,058,585 | $82,151 | +1% | 4.04% |
| 5. | Deerfield Management James E. Flynn | 4,863,725 | $78,987 | -16% | 1.54% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $16.30 | 3,069 | Officer | 7,069 | 2021-11-18 | Filing | |
| $4.00 | 62,500 | Officer, Director | 176,854 | 2019-12-10 | Filing | |
| $3.12 | 15,000 | Officer, Director | 114,354 | 2019-11-15 | Filing | |
| $1.48 | 25,000 | Officer, Director | 93,105 | 2019-05-10 | Filing | |
| $56.97 | 3,500 | Director | 6,000 | 2016-06-03 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $16.39 | 12,278 | Officer | 128,280 | 2022-01-03 | Filing | |
| $16.39 | 15,819 | Officer | 65,504 | 2022-01-03 | Filing | |
| $17.01 | 801 | Officer, Director | 279,133 | 2021-12-31 | Filing | |
| $17.01 | 100 | Officer, Director | 279,133 | 2021-12-30 | Filing | |
| $16.64 | 5,229 | Officer, Director | 279,133 | 2021-12-27 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 375,989 | $6,287 | 3.33% | |
| 2. | 83,242 | $1,391 | 0% | |
| 3. | 15,975 | $267 | 0.04% | |
| 4. | 11,350 | $188 | 0.04% | |
| 5. | 2,100 | $35 | 0.01% |
