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10. Sage Therapeutics Inc (NASDAQ:SAGE)

Sage Therapeutics Inc (NASDAQ:SAGE) is a clinical-stage biopharmaceutical company. It focuses on central nervous system (CNS) disorders. Sage Therapeutics Inc (NASDAQ:SAGE) has a portfolio of products targeting critical CNS receptor systems, GABA and NMDA. The company recently announced positive results from a Phase 2 clinical trial of its Sage-217. Sage’s lead program, brexanolone (SAGE-547), is in Phase 3 clinical development for postpartum depression. The company internally-develops molecules designed to restore CNS balance by improving receptor sensitivity to natural nerve signals. The company has not generated any revenue till date, but has incurred net losses in each year since its inception in 2010.

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