| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Great Point Partners Jeffrey Jay And David Kroin | 978,302 | $39,181,000 | -13% | 5.81% |
| 2. | Cadian Capital Eric Bannasch | 2,154,274 | $86,279 | +40% | 4.66% |
| 3. | Perceptive Advisors Joseph Edelman | 3,970,357 | $159,012 | 4.45% | |
| 4. | RA Capital Management Peter Kolchinsky | 1,145,268 | $45,868 | 3.51% | |
| 5. | Broadfin Capital Kevin Kotler | 537,380 | $21,522 | +18% | 3.35% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $36.59 | 1,346 | Officer | 4,033 | 2017-12-13 | Filing | |
| $37.50 | 300,000 | Large Shareholder | 3,970,357 | 2017-10-03 | Filing | |
| $27.67 | 22,055 | Large Shareholder | 3,670,357 | 2017-09-29 | Filing | |
| $40.14 | 8,920 | Large Shareholder | 3,648,302 | 2017-09-29 | Filing | |
| $39.22 | 12,586 | Large Shareholder | 3,639,382 | 2017-09-29 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $45.00 | 5,118 | Officer | 7,143 | 2018-06-12 | Filing | |
| $39.90 | 218 | Director | 0 | 2018-05-16 | Filing | |
| $44.83 | 24,716 | Director | 0 | 2018-03-12 | Filing | |
| $44.65 | 27,760 | Director | 90,575 | 2018-03-13 | Filing | |
| $44.97 | 7,240 | Director | 90,575 | 2018-03-12 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 204,546 | $8,192 | 3.92% | |
| 2. | 362,010 | $14,499 | 3.49% | |
| 3. | 278,510 | $11,154 | 2.37% | |
| 4. | 63,499 | $2,543 | 1.81% | |
| 5. | 16,268 | $652 | 0.68% |
