| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Great Point Partners Jeffrey Jay And David Kroin | 1,121,331 | $44,909 | +10% | 7.66% |
| 2. | Perceptive Advisors Joseph Edelman | 3,970,357 | $160,799 | +9% | 5.33% |
| 3. | Pura Vida Investments Efrem Kamen | 130,268 | $5,217,233 | +226% | 3.86% |
| 4. | RA Capital Management Peter Kolchinsky | 1,145,268 | $45,868 | +16% | 3.83% |
| 5. | Cadian Capital Eric Bannasch | 1,545,605 | $61,901 | 3.77% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $36.59 | 1,346 | Officer | 4,033 | 2017-12-13 | Filing | |
| $37.50 | 300,000 | Large Shareholder | 3,970,357 | 2017-10-03 | Filing | |
| $27.67 | 22,055 | Large Shareholder | 3,670,357 | 2017-09-29 | Filing | |
| $40.14 | 8,920 | Large Shareholder | 3,648,302 | 2017-09-29 | Filing | |
| $39.22 | 12,586 | Large Shareholder | 3,639,382 | 2017-09-29 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $44.83 | 24,716 | Director | 0 | 2018-03-12 | Filing | |
| $44.65 | 27,760 | Director | 90,575 | 2018-03-13 | Filing | |
| $44.97 | 7,240 | Director | 90,575 | 2018-03-12 | Filing | |
| $36.84 | 10,000 | Director | 90,575 | 2017-12-11 | Filing | |
| $36.84 | 8,462 | Director | 90,575 | 2017-12-11 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 50,000 | $2,003 | 0.24% | |
| 2. | 72 | $3 | 0% | |
| 3. | 16,865 | $675 | 0% | |
| 4. | 0 | $0 | 0% | |
| 5. | 1,094 | $44 | 0% |
