| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Consonance Capital Management Mitchell Blutt | 1,696,773 | $80,597 | 5.08% | |
| 2. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 839,954 | $39,898 | -26% | 4.79% |
| 3. | Daruma Asset Management Mariko Gordon | 747,221 | $35,493 | +61% | 4.03% |
| 4. | DAFNA Capital Management Nathan Fischel | 151,770 | $7,209 | +8% | 3.1% |
| 5. | Deerfield Management James E. Flynn | 1,608,785 | $76,417 | +6% | 2.93% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $41.75 | 2,000 | Director | 19,800 | 2018-11-16 | Filing | |
| $49.45 | 1,000 | Director | 16,050 | 2018-05-25 | Filing | |
| $50.25 | 1,000 | Director | 15,050 | 2018-05-21 | Filing | |
| $39.90 | 1,000 | Director | 12,900 | 2017-05-09 | Filing | |
| $41.80 | 1,000 | Director | 11,900 | 2017-04-19 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $47.02 | 1,500 | Officer | 95,743 | 2019-02-01 | Filing | |
| $46.03 | 9,500 | Officer | 97,243 | 2019-02-01 | Filing | |
| $35.21 | 11,000 | Officer | 106,743 | 2019-01-02 | Filing | |
| $40.55 | 299 | Officer | 117,743 | 2018-12-03 | Filing | |
| $39.79 | 10,701 | Officer | 118,042 | 2018-12-03 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,672,714 | $79,454 | 35.87% | |
| 2. | 1,950,477 | $92,648 | 24.11% | |
| 3. | 71,675 | $3,405 | 5.68% | |
| 4. | 101,811 | $4,837 | 5.02% | |
| 5. | 211,823 | $10,062 | 3.61% |
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