| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,788,774 | $11,287 | +54% | 1.47% |
| 2. | VenBio Select Advisor Kurt Von Emster | 2,400,000 | $15,144 | +2% | 0.9% |
| 3. | DAFNA Capital Management Nathan Fischel | 237,683 | $1,500 | 0.74% | |
| 4. | Eversept Partners Kamran Moghtaderi | 205,104 | $1,294 | -3% | 0.71% |
| 5. | Dorset Management David M. Knott | 173,390 | $1,094 | 0.51% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $2.22 | 15,000 | Director | 44,210 | 2017-11-15 | Filing | |
| $2.95 | 8,000 | Director | 29,210 | 2017-09-22 | Filing | |
| $2.95 | 2,000 | Director | 21,210 | 2017-09-21 | Filing | |
| $2.90 | 6,312 | Director | 19,210 | 2017-08-18 | Filing | |
| $2.65 | 23 | Director | 12,898 | 2017-08-17 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $7.85 | 30,000 | Director | 115,869 | 2016-12-15 | Filing | |
| $7.65 | 11,938 | Director | 145,869 | 2016-08-19 | Filing | |
| $7.70 | 9,599 | Director | 157,807 | 2016-08-18 | Filing | |
| $7.89 | 1,600 | Director | 167,406 | 2016-08-17 | Filing | |
| $8.25 | 6,863 | Director | 169,006 | 2016-08-16 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 537,500 | $3,392 | 2.58% | |
| 2. | 1,405,476 | $8,869 | 1.13% | |
| 3. | 449,484 | $2,836 | 0.31% | |
| 4. | 18,729 | $118 | 0.11% | |
| 5. | 424,433 | $2,678 | 0.11% |
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