| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 3,499,346 | $53,820 | 2.11% | |
| 2. | VenBio Select Advisor Kurt Von Emster | 2,800,000 | $43,064 | 0.74% | |
| 3. | OrbiMed Advisors Samuel Isaly | 2,497,917 | $38,418 | 0.33% | |
| 4. | Adage Capital Management Phill Gross And Robert Atchinson | 2,450,000 | $37,681 | 0.08% | |
| 5. | Renaissance Technologies Jim Simons | 769,977 | $11,842 | -15% | 0.01% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $2.22 | 15,000 | Director | 44,210 | 2017-11-15 | Filing | |
| $2.95 | 8,000 | Director | 29,210 | 2017-09-22 | Filing | |
| $2.95 | 2,000 | Director | 21,210 | 2017-09-21 | Filing | |
| $2.90 | 6,312 | Director | 19,210 | 2017-08-18 | Filing | |
| $2.65 | 23 | Director | 12,898 | 2017-08-17 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $14.43 | 3,000 | Officer, Director | 255,186 | 2020-06-01 | Filing | |
| $13.99 | 5,000 | Officer, Director | 258,186 | 2020-05-29 | Filing | |
| $9.51 | 10,395 | Officer, Director | 258,122 | 2019-09-20 | Filing | |
| $9.39 | 5,206 | Director | 118,955 | 2019-09-20 | Filing | |
| $9.27 | 7,600 | Director | 124,161 | 2019-09-19 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 337,831 | $5,195,842 | 0% | |
| 2. | 2,625,552 | $40,381 | 0% | |
| 3. | 1,055,726 | $16,237 | 0% | |
| 4. | 1,030,140 | $15,844 | 0.24% | |
| 5. | 992,107 | $15,259 | 0.4% |
