| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 4,798,101 | $225,991 | 10.37% | |
| 2. | Cormorant Asset Management Bihua Chen | 1,810,000 | $85,251 | -6% | 5.54% |
| 3. | Ghost Tree Capital Ken Greenberg And David Kim | 435,300 | $20,503 | -13% | 4.36% |
| 4. | 300,000 | $15,000 | 3.19% | ||
| 5. | Biotechnology Value Fund / BVF Inc Mark Lampert | 723,322 | $34,068 | -3% | 2.99% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $38.85 | 400,000 | Large Shareholder | 4,798,101 | 2018-06-11 | Filing | |
| $38.85 | 193,050 | Large Shareholder | 1,565,560 | 2018-06-07 | Filing | |
| $13.00 | 255,264 | Large Shareholder | 3,135,966 | 2017-11-16 | Filing | |
| $13.00 | 144,736 | Large Shareholder | 1,372,510 | 2017-11-16 | Filing | |
| $13.00 | 650,000 | Large Shareholder | 4,360,601 | 2017-11-16 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $58.40 | 1,862 | 50,932 | 2018-08-23 | Filing | ||
| $57.86 | 32,514 | 52,794 | 2018-08-23 | Filing | ||
| $56.88 | 17,434 | 85,308 | 2018-08-23 | Filing | ||
| $51.33 | 29 | 3,394 | 2018-06-27 | Filing | ||
| $50.15 | 736 | 3,423 | 2018-06-27 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 3,135,966 | $147,704 | 39.4% | |
| 2. | 1,565,560 | $73,738 | 8.18% | |
| 3. | 112,908 | $5,318 | 0.61% | |
| 4. | 68,981 | $3,249 | 0.48% | |
| 5. | 24,260 | $1,143 | 0.46% |
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