| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 4,535,000 | $996,067 | +5% | 17.15% |
| 2. | Perceptive Advisors Joseph Edelman | 3,693,516 | $811,244 | +8% | 8.7% |
| 3. | Baker Bros. Advisors Julian Baker And Felix Baker | 1,409,784 | $309,645 | 1.16% | |
| 4. | OrbiMed Advisors Samuel Isaly | 1,145,300 | $251,554 | -14% | 2.2% |
| 5. | Farallon Capital Thomas Steyer | 875,000 | $192,185 | 1.25% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $97.50 | 50,000 | Large Shareholder | 1,765,560 | 2020-01-10 | Filing | |
| $62.00 | 150,000 | Large Shareholder | 1,715,560 | 2019-01-17 | Filing | |
| $38.85 | 400,000 | Large Shareholder | 4,798,101 | 2018-06-11 | Filing | |
| $38.85 | 193,050 | Large Shareholder | 1,565,560 | 2018-06-07 | Filing | |
| $13.00 | 255,264 | Large Shareholder | 3,135,966 | 2017-11-16 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $194.38 | 1,340 | 30,638 | 2021-02-02 | Filing | ||
| $194.38 | 218 | 3,475 | 2021-02-02 | Filing | ||
| $192.32 | 300 | 3,693 | 2021-02-02 | Filing | ||
| $190.50 | 1,732 | 3,993 | 2021-02-02 | Filing | ||
| $207.83 | 200 | 3,475 | 2021-01-29 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 492,016 | $108,066,396 | 0.05% | |
| 2. | 7,384 | $1,621,822 | 0% | |
| 3. | 4,347 | $955,000 | 0.14% | |
| 4. | 4,280,412 | $940,151 | 0.03% | |
| 5. | 4,032,238 | $885,640 | 0.02% |
