| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 6,651,429 | $290,268,362 | +11% | 2.82% |
| 2. | VenBio Select Advisor Kurt Von Emster | 6,555,555 | $286,084,420 | +2% | 5.01% |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 5,502,710 | $240,138,264 | +7% | 8.58% |
| 4. | Siren L.L.C. Raymond Debbane | 3,428,150 | $149,604,466 | +6% | 7.74% |
| 5. | Driehaus Capital Richard Driehaus | 933,890 | $40,754,960 | -21% | 0.33% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $44.00 | 58,780 | $2,586,320.00 | 353,412 | 2025-06-30 | Filing | |
| $44.00 | 115,783 | $5,094,452.00 | 2,219,858 | 2025-06-30 | Filing | |
| $44.00 | 142,604 | $6,274,576.00 | 2,798,795 | 2025-06-30 | Filing | |
| $44.00 | 600,309 | $26,413,596.00 | 6,117,295 | 2025-06-30 | Filing | |
| $44.00 | 55,191 | $2,428,404.00 | 534,134 | 2025-06-30 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $50.00 | 4,500 | $225,000.00 | 0 | 2025-06-11 | Filing | |
| $49.04 | 5,000 | $245,185.50 | 0 | 2025-06-03 | Filing | |
| $47.00 | 4,800 | $225,600.00 | 0 | 2025-06-03 | Filing | |
| $45.50 | 7,200 | $327,600.00 | 4,800 | 2025-06-03 | Filing | |
| $49.00 | 30,000 | $1,470,000.00 | 660,482 | 2025-06-03 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 5,619,848 | $245,250,166 | 0% | |
| 2. | 5,431,994 | $237,052,223 | 0.01% | |
| 3. | 5,372,061 | $234,436,742 | 0.04% | |
| 4. | 4,896,462 | $213,681,602 | 32.26% | |
| 5. | 4,148,260 | $181,030,080 | 0% |
