| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 8,657,242 | $721,061,686 | 4.14% | |
| 2. | VenBio Select Advisor Kurt Von Emster | 7,474,747 | $622,571,678 | 6.12% | |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 5,502,710 | $458,320,716 | 14.6% | |
| 4. | Siren L.L.C. Raymond Debbane | 3,186,830 | $265,431,071 | -4% | 7.36% |
| 5. | Driehaus Capital Richard Driehaus | 1,043,583 | $86,920,028 | -3% | 0.64% |