| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 8,657,242 | $992,725,940 | 4.97% | |
| 2. | VenBio Select Advisor Kurt Von Emster | 7,474,747 | $857,129,238 | 7.7% | |
| 3. | Biotechnology Value Fund / BVF Inc Mark Lampert | 3,872,052 | $444,008,203 | -30% | 11.35% |
| 4. | Siren L.L.C. Raymond Debbane | 2,935,830 | $336,651,626 | -8% | 6.81% |
| 5. | Driehaus Capital Richard Driehaus | 919,233 | $105,408,448 | -12% | 0.61% |