| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Palo Alto Investors William Leland Edwards | 4,974,007 | $226,168 | +26% | 9.03% |
| 2. | Redmile Group Jeremy Green | 1,758,600 | $79,964 | 2.71% | |
| 3. | VenBio Select Advisor Kurt Von Emster | 1,146,436 | $52,128 | -2% | 2% |
| 4. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 368,699 | $16,765 | +15% | 1.87% |
| 5. | Armistice Capital Steven Boyd | 624,000 | $28,373 | +34% | 1.85% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $15.66 | 3,500 | Director | 295,431 | 2012-08-16 | Filing | |
| $15.50 | 1,000 | Director | 291,931 | 2012-08-15 | Filing | |
| $15.40 | 5,201 | Director | 290,931 | 2012-08-14 | Filing | |
| $20.00 | 25,000 | Director | 285,730 | 2012-04-10 | Filing | |
| $13.00 | 7,813 | Director | 25,509 | 2011-11-21 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $60.02 | 4,500 | Director | 7,618 | 2018-04-09 | Filing | |
| $61.47 | 4,500 | Director | 12,118 | 2018-03-08 | Filing | |
| $60.00 | 4,500 | Director | 16,618 | 2018-02-22 | Filing | |
| $54.09 | 3,000 | Officer | 180,571 | 2018-02-15 | Filing | |
| $59.16 | 3,000 | Officer | 183,571 | 2018-01-16 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 141,345 | $6,427 | 4.66% | |
| 2. | 95,856,000 | $103,358 | 3.18% | |
| 3. | 70,498 | $3,206 | 2.93% | |
| 4. | 101,855 | $4,631,347 | 1.44% | |
| 5. | 173,892 | $7,907 | 1.31% |
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