| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Palo Alto Investors William Leland Edwards | 3,955,660 | $208,859 | +17% | 8.93% |
| 2. | VenBio Select Advisor Kurt Von Emster | 1,165,884 | $61,559 | +6% | 2.93% |
| 3. | Iguana Healthcare Management Stuart Weisbrod | 70,000 | $3,696 | +17% | 2.43% |
| 4. | Camber Capital Management Stephen Dubois | 825,000 | $43,560 | +38% | 2.13% |
| 5. | 242,600 | $12,809 | +5% | 2.1% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $15.66 | 3,500 | Director | 295,431 | 2012-08-16 | Filing | |
| $15.50 | 1,000 | Director | 291,931 | 2012-08-15 | Filing | |
| $15.40 | 5,201 | Director | 290,931 | 2012-08-14 | Filing | |
| $20.00 | 25,000 | Director | 285,730 | 2012-04-10 | Filing | |
| $13.00 | 7,813 | Director | 25,509 | 2011-11-21 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $60.02 | 4,500 | Director | 7,618 | 2018-04-09 | Filing | |
| $61.47 | 4,500 | Director | 12,118 | 2018-03-08 | Filing | |
| $60.00 | 4,500 | Director | 16,618 | 2018-02-22 | Filing | |
| $54.09 | 3,000 | Officer | 180,571 | 2018-02-15 | Filing | |
| $59.16 | 3,000 | Officer | 183,571 | 2018-01-16 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 71,092 | $3,754 | 2.99% | |
| 2. | 87,346,000 | $101,883 | 2.41% | |
| 3. | 36,529 | $1,929 | 2.02% | |
| 4. | 101,855 | $5,377,944 | 1.71% | |
| 5. | 50,000 | $2,640 | 1.65% |
