| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 6,290,586 | $95,617 | +35% | 8.4% |
| 2. | Redmile Group Jeremy Green | 15,906,680 | $241,782 | -1% | 7.43% |
| 3. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 2,094,167 | $31,831 | +34% | 3.37% |
| 4. | Birchview Capital Matthew Strobeck | 128,000 | $1,946 | 1.25% | |
| 5. | Driehaus Capital Richard Driehaus | 2,396,733 | $36,430 | -9% | 1.12% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $16.87 | 3,000 | 3,000 | 2018-11-01 | Filing | ||
| $3.50 | 28,000 | Large Shareholder | 19,150,650 | 2016-09-15 | Filing | |
| $3.51 | 372,000 | Large Shareholder | 19,129,950 | 2016-09-14 | Filing | |
| $3.19 | 300,000 | Large Shareholder | 19,150,650 | 2016-01-20 | Filing | |
| $3.60 | 75,000 | Large Shareholder | 18,850,650 | 2016-01-12 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $18.06 | 19,720 | 3,921 | 2019-01-15 | Filing | ||
| $14.05 | 6,268 | 228,998 | 2018-12-27 | Filing | ||
| $16.21 | 115,185 | 222,298 | 2018-12-03 | Filing | ||
| $14.76 | 18,000 | 19,297 | 2018-09-19 | Filing | ||
| $15.38 | 9,687 | 210,086 | 2018-09-04 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 31,397 | $447 | 0.23% | |
| 2. | 100,000 | $1,425 | 0.18% | |
| 3. | 85,645 | $1,220 | 0.17% | |
| 4. | 118,800 | $1,693 | 0.01% | |
| 5. | 0 | $0 | 0% |
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