| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Palo Alto Investors William Leland Edwards | 1,585,413 | $297,122 | -19% | 12.79% |
| 2. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 84,774 | $15,887 | -35% | 1.98% |
| 3. | Perceptive Advisors Joseph Edelman | 215,000 | $40,293 | +316% | 1.33% |
| 4. | Coe Capital Management Mark Coe | 5,950 | $1,115 | -3% | 1.17% |
| 5. | Marshall Wace LLP Paul Marshall And Ian Wace | 477,618 | $89,510 | +265% | 0.49% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $60.17 | 7,500 | Director | 157,869 | 2015-05-29 | Filing | |
| $19.86 | 100,000 | Director | 282,398 | 2013-05-07 | Filing | |
| $15.20 | 56,017 | Director | 172,398 | 2013-02-25 | Filing | |
| $14.70 | 43,983 | Director | 116,381 | 2013-02-22 | Filing | |
| $6.86 | 15,000 | Director | 65,000 | 2009-02-27 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $273.04 | 100 | Officer | 49,087 | 2018-02-20 | Filing | |
| $272.32 | 1,800 | Officer | 49,187 | 2018-02-20 | Filing | |
| $271.28 | 3,933 | Officer | 50,987 | 2018-02-20 | Filing | |
| $270.45 | 7,540 | Officer | 54,920 | 2018-02-20 | Filing | |
| $269.48 | 4,727 | Officer | 62,460 | 2018-02-20 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 80,180 | $23,332 | 3.21% | |
| 2. | 76,490 | $22,258 | 2.74% | |
| 3. | 135,200 | $39,342 | 1.6% | |
| 4. | 137,519 | $40,017 | 0.58% | |
| 5. | 2,200 | $640 | 0.55% |
