1. Wilmington, NC
The final entry on our list of the cities with the best air quality in the U.S. is from the Old North State of North Carolina. Wilmington, or the port city, is not only an attractive tourist destination, but is also the “Coast Guard City” with various fascinating museums and the setting for notable television series including One Tree Hill. Citizens of Wilmington and from the other three entries in this category are fortunate indeed to be breathing some of the cleanest air in America!

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