| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,502,800 | $26,404 | 2.32% | |
| 2. | Opaleye Management James A. Silverman | 320,000 | $5,622 | -1% | 1.43% |
| 3. | AQR Capital Management Cliff Asness | 12,391 | $218 | 0% | |
| 4. | Two Sigma Advisors John Overdeck And David Siegel | 29,290 | $515 | -1% | 0% |
| 5. | Renaissance Technologies Jim Simons | 0 | $0 | 0% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $13.26 | 4,000 | Officer, Director | 20,333 | 2018-11-13 | Filing | |
| $3.62 | 21,410 | Large Shareholder, Director | 510,449 | 2013-08-19 | Filing | |
| $3.62 | 1,854,058 | Large Shareholder, Director | 19,767,770 | 2013-08-19 | Filing | |
| $3.62 | 882,323 | Large Shareholder, Director | 2,829,753 | 2013-08-19 | Filing | |
| $3.00 | 103,608 | Large Shareholder, Director | 463,839 | 2012-10-29 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $12.67 | 5,528 | Director | 9,144 | 2018-11-15 | Filing | |
| $24.77 | 2,655 | Officer | 6,555 | 2018-04-27 | Filing | |
| $24.69 | 8,345 | Officer | 6,555 | 2018-04-26 | Filing | |
| $24.42 | 15,655 | Officer, Director | 16,333 | 2018-04-27 | Filing | |
| $24.69 | 8,345 | Officer, Director | 16,333 | 2018-04-26 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 54,915 | $965 | 0.05% | |
| 2. | 2,600 | $46 | 0.03% | |
| 3. | 5,800 | $102 | 0.02% | |
| 4. | 51,810 | $910 | 0% | |
| 5. | 100 | $2 | 0% |
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