| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,502,800 | $53,500 | 6.44% | |
| 2. | Opaleye Management James A. Silverman | 320,200 | $11,399 | 3.65% | |
| 3. | Millennium Management Israel Englander | 196,759 | $7,005 | +1405% | 0% |
| 4. | Gotham Asset Management Joel Greenblatt | 7,513 | $267 | 0% | |
| 5. | D E Shaw D. E. Shaw | 15,647 | $557 | -80% | 0% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.62 | 21,410 | Large Shareholder, Director | 510,449 | 2013-08-19 | Filing | |
| $3.62 | 1,854,058 | Large Shareholder, Director | 19,767,770 | 2013-08-19 | Filing | |
| $3.62 | 882,323 | Large Shareholder, Director | 2,829,753 | 2013-08-19 | Filing | |
| $3.00 | 103,608 | Large Shareholder, Director | 463,839 | 2012-10-29 | Filing | |
| $3.00 | 4,282,419 | Large Shareholder, Director | 17,888,512 | 2012-10-29 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $27.44 | 2,200 | Officer, Director | 16,333 | 2017-11-15 | Filing | |
| $27.00 | 23,945 | Officer, Director | 18,533 | 2017-11-15 | Filing | |
| $30.45 | 600 | Officer, Director | 16,333 | 2017-11-14 | Filing | |
| $29.42 | 900 | Officer, Director | 16,933 | 2017-11-14 | Filing | |
| $29.05 | 3,564 | Officer, Director | 17,833 | 2017-11-14 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 10,000 | $202 | 0% | |
| 2. | 5,412 | $110 | 0% | |
| 3. | 56,379 | $1,141 | 0% |
