| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,769,029 | $22,378 | +18% | 2.92% |
| 2. | Opaleye Management James A. Silverman | 400,000 | $5,060 | +25% | 1.88% |
| 3. | Two Sigma Advisors John Overdeck And David Siegel | 32,195 | $407 | +10% | 0% |
| 4. | AQR Capital Management Cliff Asness | 0 | $0 | 0% | |
| 5. | Royce & Associates Chuck Royce | 0 | $0 | 0% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $14.19 | 25,000 | Large Shareholder | 718,541 | 2018-12-17 | Filing | |
| $14.41 | 24,253 | Large Shareholder | 693,541 | 2018-12-13 | Filing | |
| $14.75 | 2,810 | Large Shareholder | 669,288 | 2018-12-12 | Filing | |
| $14.50 | 9,400 | Large Shareholder | 666,478 | 2018-12-11 | Filing | |
| $14.54 | 18,081 | Large Shareholder | 657,078 | 2018-12-10 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $12.67 | 5,528 | Director | 9,144 | 2018-11-15 | Filing | |
| $24.77 | 2,655 | Officer | 6,555 | 2018-04-27 | Filing | |
| $24.69 | 8,345 | Officer | 6,555 | 2018-04-26 | Filing | |
| $24.42 | 15,655 | Officer, Director | 16,333 | 2018-04-27 | Filing | |
| $24.69 | 8,345 | Officer, Director | 16,333 | 2018-04-26 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 316,234 | $3,842 | 0.22% | |
| 2. | 11,372 | $144 | 0.08% | |
| 3. | 57,415 | $726 | 0.08% | |
| 4. | 39,595 | $501 | 0.02% | |
| 5. | 72 | $1 | 0% |
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