| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,502,800 | $30,402 | 3.08% | |
| 2. | Opaleye Management James A. Silverman | 320,200 | $6,477 | 1.85% | |
| 3. | BlueCrest Capital Mgmt. Michael Platt And William Reeves | 20,319 | $411 | 0.01% | |
| 4. | Gotham Asset Management Joel Greenblatt | 10,466 | $212 | +40% | 0% |
| 5. | Millennium Management Israel Englander | 191,289 | $3,870 | -3% | 0% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.62 | 21,410 | Large Shareholder, Director | 510,449 | 2013-08-19 | Filing | |
| $3.62 | 1,854,058 | Large Shareholder, Director | 19,767,770 | 2013-08-19 | Filing | |
| $3.62 | 882,323 | Large Shareholder, Director | 2,829,753 | 2013-08-19 | Filing | |
| $3.00 | 103,608 | Large Shareholder, Director | 463,839 | 2012-10-29 | Filing | |
| $3.00 | 4,282,419 | Large Shareholder, Director | 17,888,512 | 2012-10-29 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $24.77 | 2,655 | Officer | 6,555 | 2018-04-27 | Filing | |
| $24.69 | 8,345 | Officer | 6,555 | 2018-04-26 | Filing | |
| $24.42 | 15,655 | Officer, Director | 16,333 | 2018-04-27 | Filing | |
| $24.69 | 8,345 | Officer, Director | 16,333 | 2018-04-26 | Filing | |
| $27.44 | 2,200 | Officer, Director | 16,333 | 2017-11-15 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 162 | $3 | 0% | |
| 2. | 0 | $0 | 0% | |
| 3. | 31 | $0 | 0% | |
| 4. | 7,041 | $147 | 0% | |
| 5. | 16 | $0 | 0% |
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