| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,502,800 | $31,378 | 3.06% | |
| 2. | Opaleye Management James A. Silverman | 320,200 | $6,685 | 1.73% | |
| 3. | BlueCrest Capital Mgmt. Michael Platt And William Reeves | 0 | $0 | 0% | |
| 4. | AQR Capital Management Cliff Asness | 12,391 | $259 | 0% | |
| 5. | Gotham Asset Management Joel Greenblatt | 0 | $0 | 0% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.62 | 21,410 | Large Shareholder, Director | 510,449 | 2013-08-19 | Filing | |
| $3.62 | 1,854,058 | Large Shareholder, Director | 19,767,770 | 2013-08-19 | Filing | |
| $3.62 | 882,323 | Large Shareholder, Director | 2,829,753 | 2013-08-19 | Filing | |
| $3.00 | 103,608 | Large Shareholder, Director | 463,839 | 2012-10-29 | Filing | |
| $3.00 | 4,282,419 | Large Shareholder, Director | 17,888,512 | 2012-10-29 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $24.77 | 2,655 | Officer | 6,555 | 2018-04-27 | Filing | |
| $24.69 | 8,345 | Officer | 6,555 | 2018-04-26 | Filing | |
| $24.42 | 15,655 | Officer, Director | 16,333 | 2018-04-27 | Filing | |
| $24.69 | 8,345 | Officer, Director | 16,333 | 2018-04-26 | Filing | |
| $27.44 | 2,200 | Officer, Director | 16,333 | 2017-11-15 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 20,112 | $420 | 0.06% | |
| 2. | 52,100 | $1,087 | 0.06% | |
| 3. | 11,600 | $242 | 0.04% | |
| 4. | 2,900 | $61 | 0.04% | |
| 5. | 88,025 | $1,825 | 0.03% |
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