| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 7,593,303 | $322,715,378 | +194% | 8.25% |
| 2. | Woodline Partners Michael Rockefeller And Karl Kroeker | 1,114,363 | $47,360,428 | +75% | 0.15% |
| 3. | Newtyn Management Noah Levy And Eugene Dozortsev | 709,247 | $30,142,997 | 3.76% | |
| 4. | Opaleye Management James A. Silverman | 338,374 | $14,380,895 | +13% | 1.3% |
| 5. | Water Island Capital John Orrico | 242,000 | $10,285,000 | 0.96% |