| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Palo Alto Investors William Leland Edwards | 1,625,234 | $183,895 | +1% | 7.34% |
| 2. | Consonance Capital Management Mitchell Blutt | 566,926 | $64,148 | 4.13% | |
| 3. | Great Point Partners Jeffrey Jay And David Kroin | 169,639 | $19,195 | 2.71% | |
| 4. | Mountain Lake Investment Management Mitch Cantor | 18,000 | $2,037 | -13% | 1.03% |
| 5. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 2,660 | $301 | +4% | 0.65% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $52.38 | 1,167 | Officer, Director | 709,769 | 2012-12-28 | Filing | |
| $52.41 | 3,000 | Officer, Director | 708,602 | 2012-12-27 | Filing | |
| $52.34 | 3,000 | Officer, Director | 705,602 | 2012-12-26 | Filing | |
| $52.45 | 3,000 | Officer, Director | 702,602 | 2012-12-24 | Filing | |
| $52.12 | 3,000 | Officer, Director | 699,602 | 2012-12-21 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $119.00 | 810 | Director | 1,555 | 2018-09-10 | Filing | |
| $118.00 | 810 | Director | 2,365 | 2018-09-06 | Filing | |
| $129.38 | 3,240 | Director | 0 | 2018-08-16 | Filing | |
| $113.07 | 3,240 | Director | 0 | 2018-06-29 | Filing | |
| $112.38 | 600 | Director | 2,890 | 2018-06-12 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 552,019 | $62,461 | 15.95% | |
| 2. | 33,778 | $3,822 | 3.7% | |
| 3. | 118,703 | $13,431 | 2.9% | |
| 4. | 68,193 | $7,716 | 1.74% | |
| 5. | 37,690 | $4,265 | 1.72% |
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