| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Palo Alto Investors William Leland Edwards | 1,625,234 | $207,835 | 8.4% | |
| 2. | Great Point Partners Jeffrey Jay And David Kroin | 300,000 | $38,364 | +77% | 5.97% |
| 3. | Consonance Capital Management Mitchell Blutt | 862,295 | $110,270 | +53% | 5.93% |
| 4. | Armistice Capital Steven Boyd | 292,000 | $37,341 | 2.24% | |
| 5. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 2,805 | $359 | +6% | 0.85% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $52.38 | 1,167 | Officer, Director | 709,769 | 2012-12-28 | Filing | |
| $52.41 | 3,000 | Officer, Director | 708,602 | 2012-12-27 | Filing | |
| $52.34 | 3,000 | Officer, Director | 705,602 | 2012-12-26 | Filing | |
| $52.45 | 3,000 | Officer, Director | 702,602 | 2012-12-24 | Filing | |
| $52.12 | 3,000 | Officer, Director | 699,602 | 2012-12-21 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $119.00 | 810 | Director | 1,555 | 2018-09-10 | Filing | |
| $118.00 | 810 | Director | 2,365 | 2018-09-06 | Filing | |
| $129.38 | 3,240 | Director | 0 | 2018-08-16 | Filing | |
| $113.07 | 3,240 | Director | 0 | 2018-06-29 | Filing | |
| $112.38 | 600 | Director | 2,890 | 2018-06-12 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 37,484 | $4,793 | 1.93% | |
| 2. | 10,183 | $1,302 | 0.88% | |
| 3. | 512,427 | $65,528 | 0.83% | |
| 4. | 20,867 | $2,668 | 0.66% | |
| 5. | 34,000 | $4,348 | 0.65% |
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