| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | RA Capital Management Peter Kolchinsky | 4,278,796 | $56,266 | +74% | 3.65% |
| 2. | VenBio Select Advisor Kurt Von Emster | 4,950,031 | $65,093 | -6% | 2.5% |
| 3. | Opaleye Management James A. Silverman | 625,000 | $8,218 | +128% | 2.12% |
| 4. | Bridger Management Roberto Mignone | 2,190,085 | $28,800 | -8% | 1.56% |
| 5. | Pura Vida Investments Efrem Kamen | 50,000 | $658 | 0.55% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $6.53 | 114,855 | Large Shareholder | 5,114,855 | 2015-02-17 | Filing | |
| $3.43 | 10,000 | Large Shareholder, Officer, Director | 7,839,471 | 2013-12-11 | Filing | |
| $2.00 | 1,000 | Director | 51,265 | 2012-12-06 | Filing | |
| $2.28 | 3,400 | Officer | 504,400 | 2012-09-14 | Filing | |
| $2.25 | 1,000 | Officer | 501,000 | 2012-09-13 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $13.19 | 35,000 | 438,267 | 2018-07-03 | Filing | ||
| $13.26 | 12,191 | 473,267 | 2018-07-02 | Filing | ||
| $13.45 | 25,071 | 60,330 | 2018-06-14 | Filing | ||
| $8.50 | 32,006 | 485,458 | 2018-01-02 | Filing | ||
| $11.04 | 30,000 | 447,464 | 2017-06-19 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 195,463 | $2,570 | 1.7% | |
| 2. | 31,594 | $415 | 1.19% | |
| 3. | 59,022 | $776 | 0.68% | |
| 4. | 80,000 | $1,052 | 0.5% | |
| 5. | 160,000 | $2,104 | 0.23% |
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