| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 783,910 | $3,888 | 0.18% | |
| 2. | DAFNA Capital Management Nathan Fischel | 60,000 | $298 | 0.14% | |
| 3. | Deerfield Management James E. Flynn | 318,000 | $1,577 | 0.05% | |
| 4. | 900,000 | $4,464 | 0.04% | ||
| 5. | BlueCrest Capital Mgmt. Michael Platt And William Reeves | 173,282 | $859 | 0.02% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.84 | 8,103 | Director | 22,001 | 2018-03-06 | Filing | |
| $3.88 | 6,300 | Director | 6,300 | 2018-03-06 | Filing | |
| $3.89 | 6,300 | Director | 6,300 | 2018-03-06 | Filing | |
| $3.96 | 2,418 | Director | 2,500 | 2018-03-06 | Filing | |
| $3.96 | 2,418 | Director | 2,500 | 2018-03-06 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $6.52 | 15,000 | Officer | 7,763 | 2016-08-01 | Filing | |
| $10.61 | 2,000 | Officer | 5,295 | 2016-05-02 | Filing | |
| $10.00 | 2,000 | Officer | 5,295 | 2016-04-22 | Filing | |
| $10.01 | 4,000 | Officer | 5,295 | 2016-03-07 | Filing | |
| $11.47 | 2,000 | Officer | 5,295 | 2016-01-04 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 4,734,238 | $23,482 | 5.15% | |
| 2. | 500,000 | $2,480 | 2.4% | |
| 3. | 1,346,360 | $6,678 | 1.09% | |
| 4. | 1,000,000 | $4,960 | 0.37% | |
| 5. | 2,496,194 | $12,381 | 0.18% |
