| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 319,866 | $20,638 | +136% | 2.46% |
| 2. | Redmile Group Jeremy Green | 1,166,032 | $75,232 | +37% | 2.12% |
| 3. | Atika Capital Brad Farber | 117,000 | $7,549 | +30% | 1.48% |
| 4. | Columbus Circle Investors Principal Global Investors | 799,623 | $51,592 | -2% | 1.37% |
| 5. | Driehaus Capital Richard Driehaus | 465,059 | $30,006 | -4% | 0.94% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $37.75 | 1,300 | Director | 3,054 | 2018-11-05 | Filing | |
| $28.50 | 1,754 | Director | 1,754 | 2018-08-03 | Filing | |
| $3.84 | 8,103 | Director | 22,001 | 2018-03-06 | Filing | |
| $3.88 | 6,300 | Director | 6,300 | 2018-03-06 | Filing | |
| $3.89 | 6,300 | Director | 6,300 | 2018-03-06 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $70.03 | 9,538 | Officer | 2,501 | 2019-09-06 | Filing | |
| $72.00 | 2,000 | Officer | 3,311 | 2019-09-03 | Filing | |
| $71.01 | 80,000 | Officer, Director | 891,750 | 2019-08-29 | Filing | |
| $70.77 | 20,000 | Officer, Director | 971,750 | 2019-08-28 | Filing | |
| $71.00 | 162 | Director | 9,670 | 2019-08-28 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 100,000 | $6,452 | 4.46% | |
| 2. | 228,000 | $14,711 | 3.66% | |
| 3. | 215,920 | $13,931 | 2.53% | |
| 4. | 509,876 | $32,897 | 2.39% | |
| 5. | 98,325 | $6,344 | 2.06% |
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