| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Siren L.L.C. Raymond Debbane | 9,575,013 | $526,625,715 | -12% | 10.66% |
| 2. | Samsara BioCapital Srini Akkaraju And Michael Dybbs | 6,897,652 | $379,370,860 | 31.16% | |
| 3. | Orbis Investment Management William B. Gray | 5,933,533 | $326,344,315 | +42% | 1.12% |
| 4. | Redmile Group Jeremy Green | 4,311,092 | $237,110,060 | -53% | 15.92% |
| 5. | Hood River Capital Management David Swank | 2,224,788 | $122,363,340 | +9% | 0.89% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $40.97 | 4,403 | $180,390.91 | 530,038 | 2025-10-07 | Filing | |
| $40.18 | 12,400 | $498,232.00 | 525,635 | 2025-10-07 | Filing | |
| $39.31 | 12,796 | $503,010.76 | 513,235 | 2025-10-07 | Filing | |
| $39.52 | 13,748 | $543,320.96 | 500,439 | 2025-10-06 | Filing | |
| $38.68 | 80,863 | $3,127,780.84 | 486,691 | 2025-10-06 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $54.88 | 15 | $823.14 | 27,856 | 2026-07-01 | Filing | |
| $54.24 | 1,470 | $79,727.66 | 27,871 | 2026-07-01 | Filing | |
| $53.53 | 1,568 | $83,939.43 | 29,341 | 2026-07-01 | Filing | |
| $54.81 | 43 | $2,357.02 | 59,511 | 2026-07-01 | Filing | |
| $54.23 | 1,155 | $62,630.68 | 59,554 | 2026-07-01 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 17,995,241 | $989,738,234 | 0.04% | |
| 2. | 9,494,084 | $522,174,620 | 0.01% | |
| 3. | 6,727,085 | $369,989,675 | 0.06% | |
| 4. | 4,767,880 | $262,233,400 | 0.01% | |
| 5. | 4,728,681 | $260,077,455 | 0.01% |
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