| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Siren L.L.C. Raymond Debbane | 10,825,013 | $532,157,639 | 14.75% | |
| 2. | Redmile Group Jeremy Green | 9,066,621 | $445,715,088 | +74% | 29.51% |
| 3. | Samsara BioCapital Srini Akkaraju And Michael Dybbs | 6,897,652 | $339,088,572 | 32.95% | |
| 4. | Orbis Investment Management William B. Gray | 4,179,983 | $205,487,964 | +22% | 0.87% |
| 5. | Hood River Capital Management David Swank | 2,049,679 | $100,762,220 | +2% | 1.01% |