| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Siren L.L.C. Raymond Debbane | 9,575,013 | $526,625,715 | -12% | 10.66% |
| 2. | Samsara BioCapital Srini Akkaraju And Michael Dybbs | 6,897,652 | $379,370,860 | 31.16% | |
| 3. | Orbis Investment Management William B. Gray | 5,933,533 | $326,344,315 | +42% | 1.12% |
| 4. | Redmile Group Jeremy Green | 4,311,092 | $237,110,060 | -53% | 15.92% |
| 5. | Hood River Capital Management David Swank | 2,224,788 | $122,363,340 | +9% | 0.89% |