| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | RA Capital Management Peter Kolchinsky | 6,666,837 | $579,814,814 | 6.14% | |
| 2. | Baker Bros. Advisors Julian Baker And Felix Baker | 5,604,483 | $487,421,887 | 2.8% | |
| 3. | Perceptive Advisors Joseph Edelman | 2,373,795 | $206,448,951 | -7% | 4.03% |
| 4. | Polar Capital Brian Ashford-Russell And Tim Woolley | 1,615,586 | $140,507,514 | +37% | 0.5% |
| 5. | Citadel Investment Group Ken Griffin | 1,418,619 | $123,377,295 | +826% | 0.02% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.17 | 10,000 | $201,713.00 | 111,335 | 2021-03-30 | Filing | |
| $26.42 | 378,501 | $9,999,996.42 | 3,074,893 | 2018-06-25 | Filing | |
| $17.00 | 100,000 | $1,700,000.00 | 2,696,392 | 2017-10-10 | Filing | |
| $17.00 | 100,000 | $1,700,000.00 | 2,696,392 | 2017-10-10 | Filing | |
| $17.00 | 550,000 | $9,350,000.00 | 4,909,956 | 2017-10-10 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $100.32 | 37,000 | $3,711,895.50 | 7,000 | 2026-06-22 | Filing | |
| $92.21 | 4,643 | $428,131.03 | 0 | 2026-05-15 | Filing | |
| $89.56 | 5,614 | $502,789.84 | 160 | 2026-03-04 | Filing | |
| $103.28 | 585 | $60,420.44 | 110,512 | 2026-02-19 | Filing | |
| $102.10 | 800 | $81,676.08 | 111,097 | 2026-02-19 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 186,491 | $20,706,096 | 0.03% | |
| 2. | 23,422 | $2,600,545 | 0.04% | |
| 3. | 7,925 | $879,913 | 0.02% | |
| 4. | 7,800 | $866,034 | 0.08% | |
| 5. | 5,523 | $613,219 | 0.01% |
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