| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 5,604,483 | $354,147,281 | 3.44% | |
| 2. | RA Capital Management Peter Kolchinsky | 5,561,359 | $351,422,275 | -9% | 5.92% |
| 3. | Perceptive Advisors Joseph Edelman | 2,418,299 | $152,812,314 | -6% | 5.67% |
| 4. | Driehaus Capital Richard Driehaus | 1,269,952 | $80,248,267 | -13% | 0.64% |
| 5. | Polar Capital Brian Ashford-Russell And Tim Woolley | 1,250,870 | $79,042,475 | +151% | 0.41% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.17 | 10,000 | $201,713.00 | 111,335 | 2021-03-30 | Filing | |
| $26.42 | 378,501 | $9,999,996.42 | 3,074,893 | 2018-06-25 | Filing | |
| $17.00 | 100,000 | $1,700,000.00 | 2,696,392 | 2017-10-10 | Filing | |
| $17.00 | 100,000 | $1,700,000.00 | 2,696,392 | 2017-10-10 | Filing | |
| $17.00 | 550,000 | $9,350,000.00 | 4,909,956 | 2017-10-10 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $112.81 | 3,412 | $384,907.72 | 8,509 | 2025-10-16 | Filing | |
| $112.06 | 8,332 | $933,645.59 | 11,921 | 2025-10-16 | Filing | |
| $110.95 | 2,693 | $298,783.50 | 20,253 | 2025-10-16 | Filing | |
| $105.30 | 16,781 | $1,767,005.74 | 8,509 | 2025-09-02 | Filing | |
| $100.07 | 4,188 | $419,090.65 | 8,509 | 2025-08-21 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 224,128 | $22,634,687 | 0.03% | |
| 2. | 221,593 | $22,378,677 | 0.02% | |
| 3. | 22,244 | $2,246,422 | 0.04% | |
| 4. | 16,721 | $1,688,654 | 0.01% | |
| 5. | 10,000 | $1,009,900 | 0.11% |
