| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Healthcor Management LP Arthur B Cohen And Joseph Healey | 400,000 | $161,616 | -36% | 5.35% |
| 2. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 2,531 | $1,023 | -7% | 2.44% |
| 3. | Harris Associates Natixis Global Asset Management | 3,173,644 | $1,282,279 | +1% | 2.01% |
| 4. | OrbiMed Advisors Samuel Isaly | 394,400 | $159,353 | +6% | 1.91% |
| 5. | Armistice Capital Steven Boyd | 75,000 | $30,303 | -42% | 1.81% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $487.01 | 2,557 | 23,880,537 | 2017-08-25 | Filing | ||
| $485.99 | 2,681 | 23,877,980 | 2017-08-25 | Filing | ||
| $485.28 | 5,723 | 23,875,299 | 2017-08-25 | Filing | ||
| $484.21 | 2,000 | 23,869,576 | 2017-08-25 | Filing | ||
| $482.87 | 4,485 | 23,867,576 | 2017-08-25 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $410.00 | 709 | Director | 12,000 | 2018-09-28 | Filing | |
| $400.00 | 2,000 | Director | 12,000 | 2018-09-27 | Filing | |
| $395.42 | 260 | Director | 0 | 2018-09-27 | Filing | |
| $394.43 | 40 | Director | 260 | 2018-09-27 | Filing | |
| $393.49 | 300 | Director | 300 | 2018-09-27 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 995,737 | $402,317 | 4.47% | |
| 2. | 104,535 | $42,236 | 3.49% | |
| 3. | 1,488,492 | $601,410 | 3.42% | |
| 4. | 33,240 | $13,430 | 3% | |
| 5. | 20,000 | $8,081 | 2.88% |
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