| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Healthcor Management LP Arthur B Cohen And Joseph Healey | 625,000 | $215,619 | 6.84% | |
| 2. | Armistice Capital Steven Boyd | 128,000 | $44,159 | +19% | 2.88% |
| 3. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 2,698 | $931 | +3% | 2.01% |
| 4. | Harris Associates Natixis Global Asset Management | 3,148,677 | $1,086,262 | +86% | 1.75% |
| 5. | OrbiMed Advisors Samuel Isaly | 372,500 | $128,509 | -62% | 1.53% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $487.01 | 2,557 | 23,880,537 | 2017-08-25 | Filing | ||
| $485.99 | 2,681 | 23,877,980 | 2017-08-25 | Filing | ||
| $485.28 | 5,723 | 23,875,299 | 2017-08-25 | Filing | ||
| $484.21 | 2,000 | 23,869,576 | 2017-08-25 | Filing | ||
| $482.87 | 4,485 | 23,867,576 | 2017-08-25 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $406.68 | 104,552 | 23,654,384 | 2018-09-06 | Filing | ||
| $380.49 | 1,500 | Director | 0 | 2018-08-22 | Filing | |
| $380.00 | 2,000 | Director | 12,000 | 2018-08-02 | Filing | |
| $371.29 | 300 | Officer, Director | 399,847 | 2018-07-10 | Filing | |
| $370.17 | 100 | Officer, Director | 400,147 | 2018-07-10 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 50,000 | $17,249 | 13.83% | |
| 2. | 59,978 | $20,692 | 8.59% | |
| 3. | 240 | $83 | 5.42% | |
| 4. | 5,220 | $1,801 | 5.19% | |
| 5. | 31,330 | $10,808 | 4.15% |
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