| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Great Point Partners Jeffrey Jay And David Kroin | 500,000 | $34,025,000 | 5.05% | |
| 2. | Redmile Group Jeremy Green | 1,095,612 | $74,556 | +20% | 2.87% |
| 3. | Partner Fund Management Christopher Medlock James | 2,032,619 | $138,320 | +12% | 2.81% |
| 4. | VenBio Select Advisor Kurt Von Emster | 825,368 | $56,166 | 2.68% | |
| 5. | OrbiMed Advisors Samuel Isaly | 2,641,661 | $179,765 | +21% | 2.22% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $82.49 | 28 | Officer | 30 | 2014-04-11 | Filing | |
| $87.35 | 2 | Officer | 2 | 2014-04-09 | Filing | |
| $38.92 | 22,549 | Large Shareholder | 5,686,668 | 2013-11-08 | Filing | |
| $39.60 | 280,700 | Large Shareholder | 5,664,119 | 2013-11-05 | Filing | |
| $40.08 | 54,200 | Large Shareholder | 5,383,419 | 2013-10-09 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $53.00 | 1,211 | Officer | 35,816 | 2018-06-01 | Filing | |
| $92.85 | 1,858 | Officer | 25,362 | 2018-01-22 | Filing | |
| $92.85 | 669 | Officer | 28,027 | 2018-01-22 | Filing | |
| $92.75 | 1,860 | Officer | 25,379 | 2018-01-22 | Filing | |
| $92.75 | 10,692 | Large Shareholder, Officer, Director | 4,155,931 | 2018-01-22 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 27,154 | $1,848 | 1.99% | |
| 2. | 39,066 | $2,658 | 1.89% | |
| 3. | 18,057 | $1,229 | 1.53% | |
| 4. | 371,840 | $25,304 | 1.01% | |
| 5. | 194,773 | $13,254 | 0.94% |
