| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Consonance Capital Management Mitchell Blutt | 2,089,117 | $123,571 | 7.97% | |
| 2. | VenBio Select Advisor Kurt Von Emster | 1,034,375 | $61,183 | +26% | 2.35% |
| 3. | OrbiMed Advisors Samuel Isaly | 2,732,881 | $161,650 | +4% | 1.92% |
| 4. | Proxima Capital Management Youlia Miteva | 47,000 | $2,780 | +57% | 1.64% |
| 5. | Partner Fund Management Christopher Medlock James | 1,596,783 | $94,450 | -22% | 1.47% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $82.49 | 28 | Officer | 30 | 2014-04-11 | Filing | |
| $87.35 | 2 | Officer | 2 | 2014-04-09 | Filing | |
| $38.92 | 22,549 | Large Shareholder | 5,686,668 | 2013-11-08 | Filing | |
| $39.60 | 280,700 | Large Shareholder | 5,664,119 | 2013-11-05 | Filing | |
| $40.08 | 54,200 | Large Shareholder | 5,383,419 | 2013-10-09 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $92.85 | 669 | Officer | 28,027 | 2018-01-22 | Filing | |
| $51.85 | 1,839 | Officer | 23,523 | 2018-07-20 | Filing | |
| $51.95 | 610 | Officer | 35,206 | 2018-07-20 | Filing | |
| $51.95 | 1,836 | Officer | 32,543 | 2018-07-20 | Filing | |
| $52.00 | 12,520 | Large Shareholder, Officer, Director | 4,179,061 | 2018-07-20 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 289,200 | $17,106 | 1.46% | |
| 2. | 275,000 | $16,266 | 1.38% | |
| 3. | 23,694 | $1,402 | 1.13% | |
| 4. | 46,300 | $2,732 | 1.04% | |
| 5. | 365,787 | $21,636 | 0.81% |
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