| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | 19,665,000 | $20,120 | +12% | 0.47% | |
| 2. | Opaleye Management James A. Silverman | 2,500,000 | $1,817 | -20% | 0.46% |
| 3. | 2,879,000 | $2,735 | 0.21% | ||
| 4. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 99,667 | $72 | 0% | |
| 5. | 0 | $0 | 0% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $0.81 | 50,000 | Officer, Director | 50,000 | 2017-05-16 | Filing | |
| $0.78 | 10,000 | Officer | 10,000 | 2015-12-14 | Filing | |
| $1.03 | 423 | Large Shareholder | 13,275,000 | 2015-10-19 | Filing | |
| $1.00 | 4,000,000 | Large Shareholder | 13,274,577 | 2015-10-19 | Filing | |
| $8.20 | 680 | Director | 1,680 | 2009-12-02 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $0.32 | 2,500,000 | Large Shareholder | 10,775,000 | 2016-12-02 | Filing | |
| $2.47 | 4,400,000 | Large Shareholder, Director | 10,066,319 | 2014-08-13 | Filing | |
| $2.47 | 4,400,000 | Large Shareholder | 10,066,319 | 2014-08-13 | Filing | |
| $5.07 | 2,330 | Director | 4,915,383 | 2013-08-15 | Filing | |
| $5.08 | 5,000 | Director | 4,917,713 | 2013-08-14 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | Ubs Oconnor LlcBOND | 8,000,000 | $7,620,000 | 0.27% |
| 2. | 18,329 | $13 | 0% | |
| 3. | 0 | $0 | 0% | |
| 4. | 56,808 | $41 | 0% | |
| 5. | 380 | $0 | 0% |
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