| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Redmile Group Jeremy Green | 2,261,088 | $134,263 | -17% | 3.76% |
| 2. | Cormorant Asset Management Bihua Chen | 2,100,000 | $124,698 | +6% | 5.79% |
| 3. | Baker Bros. Advisors Julian Baker And Felix Baker | 1,955,413 | $116,112 | +10% | 0.71% |
| 4. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,583,595 | $94,034 | -8% | 8.76% |
| 5. | Adage Capital Management Phill Gross And Robert Atchinson | 865,000 | $51,364 | +73% | 0.15% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $29.94 | 55,000 | Director | 667,600 | 2019-11-20 | Filing | |
| $33.98 | 9,196 | Director | 612,600 | 2019-10-29 | Filing | |
| $33.41 | 68,404 | Director | 603,404 | 2019-10-28 | Filing | |
| $28.00 | 357,142 | Other | 2,982,855 | 2019-10-18 | Filing | |
| $28.00 | 357,142 | Director | 2,982,855 | 2019-10-18 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $62.38 | 2,502 | Officer, Director | 810 | 2020-06-23 | Filing | |
| $61.82 | 11,983 | Officer, Director | 3,312 | 2020-06-23 | Filing | |
| $60.32 | 515 | Officer, Director | 15,295 | 2020-06-23 | Filing | |
| $61.37 | 100 | Officer | 19,096 | 2020-06-15 | Filing | |
| $60.81 | 5,004 | Officer | 19,196 | 2020-06-15 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 20,374 | $1,209,808 | 0% | |
| 2. | 17,178 | $1,020,029 | 0% | |
| 3. | 4,951,265 | $294,006 | 0.04% | |
| 4. | 3,041 | $181,000 | 0.03% | |
| 5. | 1,958,856 | $116,318 | 0% |
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