| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Samsara BioCapital Srini Akkaraju And Michael Dybbs | 306,784 | $16,806 | -20% | 8.05% |
| 2. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,716,734 | $94,043 | 7.13% | |
| 3. | Cormorant Asset Management Bihua Chen | 1,990,922 | $109,063 | +49% | 4.35% |
| 4. | Redmile Group Jeremy Green | 2,722,388 | $149,132 | +245% | 3.56% |
| 5. | Endurant Capital Management Vishal Saluja And Pham Quang | 66,157 | $3,624 | 1.14% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $29.94 | 55,000 | Director | 667,600 | 2019-11-20 | Filing | |
| $33.98 | 9,196 | Director | 612,600 | 2019-10-29 | Filing | |
| $33.41 | 68,404 | Director | 603,404 | 2019-10-28 | Filing | |
| $28.00 | 357,142 | Other | 2,982,855 | 2019-10-18 | Filing | |
| $28.00 | 357,142 | Director | 2,982,855 | 2019-10-18 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $68.52 | 76 | Officer | 4,766 | 2020-02-18 | Filing | |
| $68.13 | 2,240 | Officer | 4,842 | 2020-02-18 | Filing | |
| $67.08 | 605 | Officer | 7,082 | 2020-02-18 | Filing | |
| $65.94 | 1,350 | Officer | 7,687 | 2020-02-18 | Filing | |
| $64.91 | 545 | Officer | 9,037 | 2020-02-18 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 914,625 | $50,103 | 10.88% | |
| 2. | 1,417,258 | $77,637 | 5.59% | |
| 3. | 37,904 | $2,076 | 0.83% | |
| 4. | 58,247 | $3,191 | 0.7% | |
| 5. | 86,500 | $4,738 | 0.39% |
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