| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 3,224,328 | $88,927 | +200% | 1.37% |
| 2. | Hudson Executive Capital Douglas Braunstein And James Woolery | 378,589 | $10,441 | 1% | |
| 3. | Deerfield Management James E. Flynn | 1,002,834 | $27,658 | -25% | 0.99% |
| 4. | Driehaus Capital Richard Driehaus | 659,177 | $18,180 | 0.56% | |
| 5. | Rubric Capital Management David Rosen | 200,000 | $5,516 | 0.43% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $11.94 | 66,621 | Director | 83,752 | 2016-06-19 | Filing | |
| $11.94 | 17,131 | Director | 17,131 | 2016-06-19 | Filing | |
| $11.94 | 666,210 | Large Shareholder, Director | 666,210 | 2016-06-19 | Filing | |
| $11.94 | 171,311 | Large Shareholder, Director | 171,311 | 2016-06-19 | Filing | |
| $18.00 | 175,000 | Director | 375,000 | 2015-07-08 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $29.00 | 24,579 | Officer | 14,190 | 2019-08-08 | Filing | |
| $29.00 | 6,875 | Officer | 38,769 | 2019-08-08 | Filing | |
| $29.00 | 12,500 | Officer | 45,644 | 2019-08-08 | Filing | |
| $32.79 | 66,783 | Officer, Director | 239,645 | 2019-08-09 | Filing | |
| $32.37 | 58,217 | Officer, Director | 306,428 | 2019-08-09 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 7,744,460 | $213,592 | 100% | |
| 2. | 3,100,560 | $85,513 | 7.85% | |
| 3. | 217,899 | $6,010 | 3.25% | |
| 4. | 286,468 | $7,901 | 2.59% | |
| 5. | 126,500 | $3,489 | 2.44% |
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