| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 3,224,328 | $88,927 | +200% | 1.37% |
| 2. | Hudson Executive Capital Douglas Braunstein And James Woolery | 378,589 | $10,441 | 1% | |
| 3. | Deerfield Management James E. Flynn | 1,002,834 | $27,658 | -25% | 0.99% |
| 4. | Driehaus Capital Richard Driehaus | 659,177 | $18,180 | 0.56% | |
| 5. | Rubric Capital Management David Rosen | 200,000 | $5,516 | 0.43% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $11.94 | 66,621 | Director | 83,752 | 2016-06-19 | Filing | |
| $11.94 | 17,131 | Director | 17,131 | 2016-06-19 | Filing | |
| $11.94 | 666,210 | Large Shareholder, Director | 666,210 | 2016-06-19 | Filing | |
| $11.94 | 171,311 | Large Shareholder, Director | 171,311 | 2016-06-19 | Filing | |
| $18.00 | 175,000 | Director | 375,000 | 2015-07-08 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $38.20 | 148 | Officer, Director | 1,286,906 | 2019-10-14 | Filing | |
| $32.01 | 4,032 | Officer | 31,706 | 2019-09-30 | Filing | |
| $33.53 | 500 | Officer, Director | 241,521 | 2019-09-23 | Filing | |
| $33.53 | 559 | Officer, Director | 13,254 | 2019-09-23 | Filing | |
| $33.53 | 444 | Officer | 31,706 | 2019-09-23 | Filing |
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