| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 2,888,888 | $712,226,448 | +4% | 7% |
| 2. | Soleus Capital Guy Levy | 941,059 | $232,008,686 | -8% | 8.56% |
| 3. | Redmile Group Jeremy Green | 677,705 | $167,081,391 | +3% | 12.3% |
| 4. | Hood River Capital Management David Swank | 613,302 | $151,203,475 | +2% | 1.66% |
| 5. | Citadel Investment Group Ken Griffin | 386,505 | $95,288,943 | -40% | 0.01% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.00 | 25,000 | $500,000.00 | 2,001,462 | 2018-10-18 | Filing | |
| $20.00 | 25,000 | $500,000.00 | 2,036,462 | 2018-10-18 | Filing | |
| $12.45 | 1,018 | $12,674.10 | 1,976,462 | 2018-06-06 | Filing | |
| $11.15 | 13,116 | $146,177.82 | 1,975,444 | 2018-06-06 | Filing | |
| $10.75 | 10,866 | $116,757.34 | 1,962,328 | 2018-06-05 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $276.32 | 2,638 | $728,919.50 | 85,096 | 2026-02-26 | Filing | |
| $275.28 | 5,103 | $1,404,759.96 | 87,734 | 2026-02-26 | Filing | |
| $275.00 | 700 | $192,500.00 | 92,837 | 2026-02-25 | Filing | |
| $274.90 | 2,425 | $666,626.92 | 93,537 | 2026-02-24 | Filing | |
| $269.50 | 930 | $250,636.21 | 95,962 | 2026-02-24 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 4,349,628 | $1,072,357,209 | 0.05% | |
| 2. | 3,937,817 | $970,829,404 | 0.02% | |
| 3. | 2,778,845 | $685,096,446 | 0.01% | |
| 4. | 1,342,303 | $330,931,382 | 0.01% | |
| 5. | 809,500 | $199,574,130 | 0.03% |
