| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 2,888,888 | $1,073,713,003 | 9.64% | |
| 2. | Soleus Capital Guy Levy | 939,254 | $349,092,534 | -19% | 12.03% |
| 3. | Hood River Capital Management David Swank | 663,375 | $246,556,586 | +8% | 1.79% |
| 4. | Redmile Group Jeremy Green | 632,005 | $234,897,298 | -7% | 15.77% |
| 5. | Woodline Partners Michael Rockefeller And Karl Kroeker | 150,616 | $55,979,449 | 0.17% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.00 | 25,000 | $500,000.00 | 2,001,462 | 2018-10-18 | Filing | |
| $20.00 | 25,000 | $500,000.00 | 2,036,462 | 2018-10-18 | Filing | |
| $12.45 | 1,018 | $12,674.10 | 1,976,462 | 2018-06-06 | Filing | |
| $11.15 | 13,116 | $146,177.82 | 1,975,444 | 2018-06-06 | Filing | |
| $10.75 | 10,866 | $116,757.34 | 1,962,328 | 2018-06-05 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $333.23 | 40 | $13,329.20 | 50,000 | 2026-08-14 | Filing | |
| $331.43 | 3,095 | $1,025,786.06 | 50,040 | 2026-08-14 | Filing | |
| $330.36 | 4,896 | $1,617,422.00 | 53,135 | 2026-08-14 | Filing | |
| $329.60 | 7,428 | $2,448,279.94 | 58,031 | 2026-08-14 | Filing | |
| $328.52 | 1,687 | $554,205.14 | 65,459 | 2026-08-14 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 4,418,197 | $1,642,111,282 | 0.07% | |
| 2. | 4,181,432 | $1,554,113,017 | 0.02% | |
| 3. | 1,574,905 | $585,344,941 | 0.03% | |
| 4. | 1,351,158 | $502,201,761 | 0.01% | |
| 5. | 1,240,567 | $461,081,537 | 0.01% |
