| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 2,888,888 | $746,257,548 | 7.34% | |
| 2. | Soleus Capital Guy Levy | 1,153,087 | $297,865,434 | +23% | 12.06% |
| 3. | Hood River Capital Management David Swank | 619,586 | $160,051,456 | +2% | 1.6% |
| 4. | Marshall Wace LLP Paul Marshall And Ian Wace | 68,343 | $17,654,364 | -63% | 0.02% |
| 5. | Fisher Asset Management Ken Fisher | 27,784 | $7,177,334 | +634% | 0% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.00 | 25,000 | $500,000.00 | 2,001,462 | 2018-10-18 | Filing | |
| $20.00 | 25,000 | $500,000.00 | 2,036,462 | 2018-10-18 | Filing | |
| $12.45 | 1,018 | $12,674.10 | 1,976,462 | 2018-06-06 | Filing | |
| $11.15 | 13,116 | $146,177.82 | 1,975,444 | 2018-06-06 | Filing | |
| $10.75 | 10,866 | $116,757.34 | 1,962,328 | 2018-06-05 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $266.42 | 1,700 | $452,918.08 | 1,403,155 | 2026-03-04 | Filing | |
| $265.16 | 6,000 | $1,590,979.20 | 1,404,855 | 2026-03-04 | Filing | |
| $264.64 | 4,852 | $1,284,019.21 | 1,410,855 | 2026-03-04 | Filing | |
| $263.58 | 2,248 | $592,534.81 | 1,415,707 | 2026-03-04 | Filing | |
| $262.35 | 1,938 | $508,430.23 | 1,417,955 | 2026-03-04 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 3,940,456 | $1,017,898,595 | 0.02% | |
| 2. | 1,456,727 | $376,301,719 | 0.02% | |
| 3. | 1,165,324 | $301,026,496 | 0.01% | |
| 4. | 824,720 | $213,041,670 | 0.03% | |
| 5. | 468,990 | $121,130,310 | 0.03% |
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