| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Frazier Healthcare Partners Alan Frazier | 895,000 | $49,565 | 8.31% | |
| 2. | Redmile Group Jeremy Green | 1,090,200 | $60,375 | +2% | 1.44% |
| 3. | OrbiMed Advisors Samuel Isaly | 994,808 | $55,092 | +66% | 0.78% |
| 4. | Consonance Capital Management Mitchell Blutt | 203,788 | $11,286 | -10% | 0.68% |
| 5. | Atika Capital Brad Farber | 58,319 | $3,230 | 0.63% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.00 | 25,000 | Large Shareholder, Officer, Director | 2,001,462 | 2018-10-18 | Filing | |
| $20.00 | 25,000 | Large Shareholder, Officer, Director | 2,036,462 | 2018-10-18 | Filing | |
| $12.45 | 1,018 | Large Shareholder, Officer, Director | 1,976,462 | 2018-06-06 | Filing | |
| $11.15 | 13,116 | Large Shareholder, Officer, Director | 1,975,444 | 2018-06-06 | Filing | |
| $10.75 | 10,866 | Large Shareholder, Officer, Director | 1,962,328 | 2018-06-05 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $63.31 | 239 | Large Shareholder, Officer, Director | 1,951,462 | 2019-12-18 | Filing | |
| $62.65 | 5,756 | Large Shareholder, Officer, Director | 1,951,701 | 2019-12-18 | Filing | |
| $61.28 | 900 | Large Shareholder, Officer, Director | 1,957,457 | 2019-12-18 | Filing | |
| $60.19 | 1,017 | Large Shareholder, Officer, Director | 1,958,357 | 2019-12-18 | Filing | |
| $59.49 | 1,200 | Large Shareholder, Officer, Director | 1,959,374 | 2019-12-18 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 60,215 | $3,335 | 2.73% | |
| 2. | 65,463 | $3,625 | 0.79% | |
| 3. | 30,070 | $1,665 | 0.66% | |
| 4. | 74,418 | $4,121 | 0.42% | |
| 5. | 86,280 | $4,778 | 0.39% |
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