| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 2,888,888 | $746,257,548 | 7.34% | |
| 2. | Soleus Capital Guy Levy | 1,153,087 | $297,865,434 | +23% | 12.06% |
| 3. | Redmile Group Jeremy Green | 673,505 | $173,979,812 | -1% | 11.52% |
| 4. | Hood River Capital Management David Swank | 619,586 | $160,051,456 | +2% | 1.6% |
| 5. | Braidwell LP Alex Karnal | 182,425 | $47,124,026 | -10% | 1.57% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.00 | 25,000 | $500,000.00 | 2,001,462 | 2018-10-18 | Filing | |
| $20.00 | 25,000 | $500,000.00 | 2,036,462 | 2018-10-18 | Filing | |
| $12.45 | 1,018 | $12,674.10 | 1,976,462 | 2018-06-06 | Filing | |
| $11.15 | 13,116 | $146,177.82 | 1,975,444 | 2018-06-06 | Filing | |
| $10.75 | 10,866 | $116,757.34 | 1,962,328 | 2018-06-05 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $347.27 | 1,000 | $347,270.00 | 0 | 2026-06-25 | Filing | |
| $311.65 | 240 | $74,796.00 | 1,378,155 | 2026-06-04 | Filing | |
| $310.94 | 2,039 | $634,000.54 | 1,378,395 | 2026-06-04 | Filing | |
| $309.95 | 2,801 | $868,156.23 | 1,380,434 | 2026-06-04 | Filing | |
| $308.89 | 3,803 | $1,174,707.91 | 1,383,235 | 2026-06-04 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 4,373,987 | $1,129,888,252 | 0.06% | |
| 2. | 3,940,456 | $1,017,898,595 | 0.02% | |
| 3. | 1,456,727 | $376,301,719 | 0.01% | |
| 4. | 1,314,434 | $339,544,591 | 0.01% | |
| 5. | 1,165,324 | $301,026,496 | 0% |
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