| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Redmile Group Jeremy Green | 1,815,698 | $120,817 | -1% | 3.77% |
| 2. | Point72 Asset Management Steve Cohen | 1,720,267 | $114,467 | -8% | 0.45% |
| 3. | VenBio Select Advisor Kurt Von Emster | 1,005,000 | $66,873 | +112% | 1.22% |
| 4. | Baker Bros. Advisors Julian Baker And Felix Baker | 807,735 | $53,747 | 0.3% | |
| 5. | Soleus Capital Guy Levy | 289,337 | $19,252 | +27% | 2.48% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.00 | 25,000 | Large Shareholder, Officer, Director | 2,001,462 | 2018-10-18 | Filing | |
| $20.00 | 25,000 | Large Shareholder, Officer, Director | 2,036,462 | 2018-10-18 | Filing | |
| $12.45 | 1,018 | Large Shareholder, Officer, Director | 1,976,462 | 2018-06-06 | Filing | |
| $11.15 | 13,116 | Large Shareholder, Officer, Director | 1,975,444 | 2018-06-06 | Filing | |
| $10.75 | 10,866 | Large Shareholder, Officer, Director | 1,962,328 | 2018-06-05 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $70.50 | 100,000 | Large Shareholder, Officer, Director | 50,000 | 2021-12-10 | Filing | |
| $70.50 | 100,000 | Director | 266,362 | 2021-12-10 | Filing | |
| $70.50 | 100,000 | Large Shareholder, Officer, Director | 50,000 | 2021-12-10 | Filing | |
| $47.29 | 1,126 | Large Shareholder, Officer, Director | 1,836,064 | 2020-09-17 | Filing | |
| $46.63 | 7,437 | Large Shareholder, Officer, Director | 1,837,190 | 2020-09-17 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 24,500 | $1,630,230 | 0% | |
| 2. | 15,207 | $1,011,874 | 0% | |
| 3. | 2,341 | $155,770 | 0% | |
| 4. | 2,106,492 | $140,166 | 0.01% | |
| 5. | 1,683,511 | $112,020 | 0% |
