| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Samsara BioCapital Srini Akkaraju And Michael Dybbs | 403,688 | $50,025 | 23.96% | |
| 2. | 754,900 | $93,547 | 15.15% | ||
| 3. | Rima Senvest Management Richard Mashaal | 1,219,121 | $151,073 | +5% | 10.27% |
| 4. | Sarissa Capital Management Alex Denner | 860,000 | $106,571 | +2% | 8.84% |
| 5. | LMR Partners Ben Levine, Andrew Manuel And Stefan Renold | 14,000,000 | $1,858,500 | 3.04% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $60.32 | 5,207 | Director | 403,688 | 2019-08-28 | Filing | |
| $64.30 | 1,180 | Director | 398,481 | 2019-08-22 | Filing | |
| $67.12 | 29,000 | Director | 397,301 | 2019-08-21 | Filing | |
| $65.85 | 37,604 | Director | 368,301 | 2019-08-20 | Filing | |
| $83.50 | 1,200 | Director | 7,556 | 2019-05-14 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $94.04 | 723 | Officer | 17,837 | 2020-01-27 | Filing | |
| $113.02 | 732 | Officer | 6,303 | 2020-01-07 | Filing | |
| $125.00 | 100 | Officer, Director | 469,126 | 2019-12-31 | Filing | |
| $125.00 | 262 | Officer | 18,722 | 2019-12-31 | Filing | |
| $117.16 | 259 | Officer | 10,580 | 2019-01-03 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 3,485,000 | $4,611 | 2.31% | |
| 2. | 290,731 | $36,028 | 1.51% | |
| 3. | 50,260 | $6,228 | 1.43% | |
| 4. | 715,176 | $88,624 | 1.4% | |
| 5. | 1,222 | $15,143 | 1.33% |
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