| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Samsara BioCapital Srini Akkaraju And Michael Dybbs | 234,375 | $23,623 | 22.67% | |
| 2. | 200,000 | $20,158 | 2.54% | ||
| 3. | 57,791,000 | $53,020 | +61% | 2.12% | |
| 4. | Sarissa Capital Management Alex Denner | 54,000 | $5,442 | -80% | 1.2% |
| 5. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 3,534 | $356 | -12% | 0.78% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $64.00 | 1,171 | Director | 5,001 | 2018-04-09 | Filing | |
| $64.00 | 7,812 | Officer, Director | 576,564 | 2018-04-09 | Filing | |
| $64.00 | 7,812 | Director | 11,642 | 2018-04-09 | Filing | |
| $64.00 | 390,625 | 6,845,578 | 2018-04-09 | Filing | ||
| $64.00 | 390,625 | 6,845,578 | 2018-04-09 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $111.51 | 2,000 | Officer | 40,543 | 2019-02-15 | Filing | |
| $104.93 | 1,313 | Officer | 18,807 | 2019-01-07 | Filing | |
| $97.48 | 474 | Officer | 37,243 | 2019-01-04 | Filing | |
| $97.45 | 699 | Officer | 37,717 | 2019-01-03 | Filing | |
| $98.28 | 2,000 | Officer | 38,416 | 2019-01-02 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 600,000 | $60,474 | 7.47% | |
| 2. | 834,600 | $84,136 | 5.76% | |
| 3. | 5,324,000 | $4,995 | 3.92% | |
| 4. | 32,500,000 | $30,048 | 2.05% | |
| 5. | 575,719 | $58,027 | 1.85% |
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