| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 16,064,461 | $259,602 | +9% | 16.82% |
| 2. | Ghost Tree Capital Ken Greenberg And David Kim | 1,538,000 | $24,854 | -22% | 5.82% |
| 3. | 1,300,000 | $21,008 | 4.92% | ||
| 4. | Iguana Healthcare Management Stuart Weisbrod | 450,000 | $7,272 | -10% | 4.73% |
| 5. | Opaleye Management James A. Silverman | 898,800 | $14,524 | 4.65% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $10.97 | 175,000 | Large Shareholder, Director, Other | 16,064,461 | 2017-11-15 | Filing | |
| $10.39 | 1,150,000 | Large Shareholder, Director, Other | 15,889,461 | 2017-11-14 | Filing | |
| $10.97 | 175,000 | Large Shareholder, Director, Other | 16,064,461 | 2017-11-15 | Filing | |
| $10.39 | 1,150,000 | Large Shareholder, Director, Other | 15,889,461 | 2017-11-14 | Filing | |
| $0.91 | 10,000 | Large Shareholder, Officer, Director | 3,887,993 | 2009-03-05 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $17.75 | 20,000 | Director | 5,613,252 | 2018-03-07 | Filing | |
| $17.60 | 20,000 | Director | 5,633,252 | 2018-03-07 | Filing | |
| $17.17 | 20,000 | Director | 5,653,252 | 2018-03-05 | Filing | |
| $17.30 | 20,000 | Director | 5,673,252 | 2018-03-05 | Filing | |
| $17.09 | 17,729 | Director | 5,693,252 | 2018-02-28 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 415,330 | $6,068 | 0.74% | |
| 2. | 13,000 | $190 | 0.12% | |
| 3. | 15,474 | $226 | 0.08% | |
| 4. | 12,500 | $183 | 0.05% | |
| 5. | 2,500,000 | $7,324 | 0.04% |
