| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 17,714,461 | $419,301 | +5% | 16.14% |
| 2. | Ghost Tree Capital Ken Greenberg And David Kim | 1,250,000 | $29,588 | -33% | 8.7% |
| 3. | Nexthera Capital Ori Hershkovitz | 1,329,104 | $31,460 | +23% | 4.87% |
| 4. | RA Capital Management Peter Kolchinsky | 3,119,778 | $73,845 | 4.79% | |
| 5. | Palo Alto Investors William Leland Edwards | 4,803,364 | $113,696 | +1% | 4.54% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $23.39 | 200,000 | Large Shareholder, Director, Other | 17,714,461 | 2018-06-15 | Filing | |
| $24.00 | 575,000 | Large Shareholder, Director, Other | 17,514,461 | 2018-06-15 | Filing | |
| $10.97 | 175,000 | Large Shareholder, Director, Other | 16,064,461 | 2017-11-15 | Filing | |
| $10.39 | 1,150,000 | Large Shareholder, Director, Other | 15,889,461 | 2017-11-14 | Filing | |
| $10.97 | 175,000 | Large Shareholder, Director, Other | 16,064,461 | 2017-11-15 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $17.75 | 20,000 | Director | 5,613,252 | 2018-03-07 | Filing | |
| $17.60 | 20,000 | Director | 5,633,252 | 2018-03-07 | Filing | |
| $17.17 | 20,000 | Director | 5,653,252 | 2018-03-05 | Filing | |
| $17.30 | 20,000 | Director | 5,673,252 | 2018-03-05 | Filing | |
| $17.09 | 17,729 | Director | 5,693,252 | 2018-02-28 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 4,750,000 | $112,433 | 20.01% | |
| 2. | 2,541,729 | $60,163 | 12.95% | |
| 3. | 1,231,543 | $29,151 | 9.93% | |
| 4. | 2,682,100 | $63,458 | 4.77% | |
| 5. | 2,411,600 | $57,058 | 4.29% |
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