| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 17,714,461 | $368,992 | 16.94% | |
| 2. | Nexthera Capital Ori Hershkovitz | 1,398,577 | $29,132 | +6% | 5.58% |
| 3. | Palo Alto Investors William Leland Edwards | 5,013,764 | $104,437 | +5% | 4.22% |
| 4. | Ghost Tree Capital Ken Greenberg And David Kim | 883,823 | $18,410 | -30% | 3.92% |
| 5. | RA Capital Management Peter Kolchinsky | 3,119,778 | $64,985 | 3.47% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $23.39 | 200,000 | Large Shareholder, Director, Other | 17,714,461 | 2018-06-15 | Filing | |
| $24.00 | 575,000 | Large Shareholder, Director, Other | 17,514,461 | 2018-06-15 | Filing | |
| $10.97 | 175,000 | Large Shareholder, Director, Other | 16,064,461 | 2017-11-15 | Filing | |
| $10.39 | 1,150,000 | Large Shareholder, Director, Other | 15,889,461 | 2017-11-14 | Filing | |
| $10.97 | 175,000 | Large Shareholder, Director, Other | 16,064,461 | 2017-11-15 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $17.75 | 20,000 | Director | 5,613,252 | 2018-03-07 | Filing | |
| $17.60 | 20,000 | Director | 5,633,252 | 2018-03-07 | Filing | |
| $17.17 | 20,000 | Director | 5,653,252 | 2018-03-05 | Filing | |
| $17.30 | 20,000 | Director | 5,673,252 | 2018-03-05 | Filing | |
| $17.09 | 17,729 | Director | 5,693,252 | 2018-02-28 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 2,055,500 | $42,816 | 15.27% | |
| 2. | 2,691,729 | $56,069 | 12.37% | |
| 3. | 1,231,543 | $25,653 | 8.41% | |
| 4. | 1,151,622 | $23,988 | 3.87% | |
| 5. | 3,403,000 | $70,918 | 3.5% |
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