| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 21,000,000 | $278,460 | 11.61% | |
| 2. | Palo Alto Investors William Leland Edwards | 6,184,320 | $82,004 | -8% | 5.46% |
| 3. | 1,201,000 | $18,015 | +51% | 4.57% | |
| 4. | Ghost Tree Capital Ken Greenberg And David Kim | 725,000 | $9,614 | +21% | 2.44% |
| 5. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 909,822 | $12,064 | +118% | 2.08% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $17.50 | 2,000,000 | Large Shareholder, Director, Other | 24,500,000 | 2019-12-05 | Filing | |
| $14.10 | 500,000 | Large Shareholder, Director, Other | 22,500,000 | 2019-10-03 | Filing | |
| $13.23 | 1,000,000 | Large Shareholder, Director, Other | 22,000,000 | 2019-10-02 | Filing | |
| $14.18 | 5,000 | Officer | 10,000 | 2019-10-03 | Filing | |
| $13.84 | 250,000 | Large Shareholder, Director, Other | 21,000,000 | 2019-06-28 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $17.75 | 20,000 | Director | 5,613,252 | 2018-03-07 | Filing | |
| $17.60 | 20,000 | Director | 5,633,252 | 2018-03-07 | Filing | |
| $17.17 | 20,000 | Director | 5,653,252 | 2018-03-05 | Filing | |
| $17.30 | 20,000 | Director | 5,673,252 | 2018-03-05 | Filing | |
| $17.09 | 17,729 | Director | 5,693,252 | 2018-02-28 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,956,362 | $25,941 | 9.9% | |
| 2. | 367,636 | $4,875 | 1.57% | |
| 3. | 1,434,900 | $19,027 | 0.46% | |
| 4. | 974,857 | $12,927 | 0.46% | |
| 5. | 536,288 | $7,111 | 0.39% |
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