| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 26,250,000 | $930,300 | +8% | 18.39% |
| 2. | Palo Alto Investors William Leland Edwards | 5,182,983 | $183,685 | -3% | 11.02% |
| 3. | Alkeon Capital Management Panayotis Takis Sparaggis | 4,616,975 | $163,626 | +49% | 0.41% |
| 4. | Point72 Asset Management Steve Cohen | 4,357,664 | $154,436 | +25% | 1% |
| 5. | Redmile Group Jeremy Green | 3,489,900 | $123,682 | 2.28% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $28.50 | 1,750,000 | Large Shareholder, Director, Other | 26,250,000 | 2020-05-01 | Filing | |
| $17.50 | 2,000,000 | Large Shareholder, Director, Other | 24,500,000 | 2019-12-05 | Filing | |
| $14.10 | 500,000 | Large Shareholder, Director, Other | 22,500,000 | 2019-10-03 | Filing | |
| $13.23 | 1,000,000 | Large Shareholder, Director, Other | 22,000,000 | 2019-10-02 | Filing | |
| $14.18 | 5,000 | Officer | 10,000 | 2019-10-03 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $17.75 | 20,000 | Director | 5,613,252 | 2018-03-07 | Filing | |
| $17.60 | 20,000 | Director | 5,633,252 | 2018-03-07 | Filing | |
| $17.17 | 20,000 | Director | 5,653,252 | 2018-03-05 | Filing | |
| $17.30 | 20,000 | Director | 5,673,252 | 2018-03-05 | Filing | |
| $17.09 | 17,729 | Director | 5,693,252 | 2018-02-28 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 374,337 | $13,266,503 | 0% | |
| 2. | 39,026 | $1,383,081 | 0% | |
| 3. | 18,864,135 | $668,546 | 0.02% | |
| 4. | 14,114,226 | $500,208 | 0.02% | |
| 5. | 11,590,471 | $410,766 | 0.04% |
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