| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 16,939,461 | $247,486 | +6% | 11.81% |
| 2. | Ghost Tree Capital Ken Greenberg And David Kim | 1,850,000 | $27,029 | +21% | 5.46% |
| 3. | Iguana Healthcare Management Stuart Weisbrod | 400,000 | $5,844 | -12% | 3.84% |
| 4. | Palo Alto Investors William Leland Edwards | 4,796,008 | $70,070 | +1% | 2.99% |
| 5. | Nexthera Capital Ori Hershkovitz | 1,081,410 | $15,799 | +168% | 2.6% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $23.39 | 200,000 | Large Shareholder, Director, Other | 17,714,461 | 2018-06-15 | Filing | |
| $24.00 | 575,000 | Large Shareholder, Director, Other | 17,514,461 | 2018-06-15 | Filing | |
| $10.97 | 175,000 | Large Shareholder, Director, Other | 16,064,461 | 2017-11-15 | Filing | |
| $10.39 | 1,150,000 | Large Shareholder, Director, Other | 15,889,461 | 2017-11-14 | Filing | |
| $10.97 | 175,000 | Large Shareholder, Director, Other | 16,064,461 | 2017-11-15 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $17.75 | 20,000 | Director | 5,613,252 | 2018-03-07 | Filing | |
| $17.60 | 20,000 | Director | 5,633,252 | 2018-03-07 | Filing | |
| $17.17 | 20,000 | Director | 5,653,252 | 2018-03-05 | Filing | |
| $17.30 | 20,000 | Director | 5,673,252 | 2018-03-05 | Filing | |
| $17.09 | 17,729 | Director | 5,693,252 | 2018-02-28 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 455,330 | $10,778 | 1.1% | |
| 2. | 2,500,000 | $11,743 | 0.07% | |
| 3. | 216,241 | $5,118 | 0.02% | |
| 4. | 3,000 | $71 | 0.02% | |
| 5. | 200,684 | $4,750 | 0.01% |
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