| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Scopia Capital Matt Sirovich And Jeremy Mindich | 8,159,184 | $215,647 | -24% | 7.96% |
| 2. | Deerfield Management James E. Flynn | 6,462,634 | $170,807 | -6% | 6.54% |
| 3. | VenBio Select Advisor Kurt Von Emster | 4,000,000 | $105,720 | -9% | 4.57% |
| 4. | Copernicus Capital Management John W. Rende | 66,000 | $1,744 | 4.47% | |
| 5. | Paulson & Co John Paulson | 6,670,700 | $176,307 | -7% | 3.84% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $9.48 | 10,000 | Director | 25,448 | 2017-05-10 | Filing | |
| $31.32 | 10,000 | Director | 10,000 | 2015-08-19 | Filing | |
| $9.76 | 6,000 | Director | 6,000 | 2014-08-14 | Filing | |
| $6.50 | 32,075 | Director | 178,406 | 2013-12-13 | Filing | |
| $6.50 | 32,075 | Director | 178,478 | 2013-12-13 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $24.64 | 3,620 | Officer | 104,330 | 2019-06-05 | Filing | |
| $21.26 | 2,000 | Officer | 28,867 | 2019-02-25 | Filing | |
| $21.19 | 4,500 | Officer | 30,867 | 2019-02-25 | Filing | |
| $21.20 | 3,580 | Officer | 35,367 | 2019-02-25 | Filing | |
| $23.20 | 1,335 | Officer | 28,867 | 2019-02-05 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 202,527 | $5,353 | 4.33% | |
| 2. | 193,063 | $5,103 | 4.32% | |
| 3. | 270,775 | $7,157 | 3.67% | |
| 4. | 114,687 | $3,031 | 2.55% | |
| 5. | 1,263,053 | $33,382 | 2.43% |
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