| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Iguana Healthcare Management Stuart Weisbrod | 165,000 | $10,864 | +10% | 7.07% |
| 2. | Ghost Tree Capital Ken Greenberg And David Kim | 230,000 | $15,143 | 3.55% | |
| 3. | Atika Capital Brad Farber | 56,000 | $3,687 | +309% | 1.42% |
| 4. | Partner Fund Management Christopher Medlock James | 870,102 | $57,288 | +59% | 1.35% |
| 5. | 1,670 | $10,995 | +13% | 1% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $42.26 | 1,000 | Director | 1,000 | 2017-03-21 | Filing | |
| $9.93 | 5,000 | Officer | 5,000 | 2016-11-01 | Filing | |
| $10.00 | 4,400 | Director | 5,000 | 2016-07-06 | Filing | |
| $10.00 | 600 | Director | 600 | 2016-07-05 | Filing | |
| $14.85 | 7,000 | Officer, Director | 41,614 | 2016-05-04 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $70.71 | 200 | Director | 623,726 | 2018-03-29 | Filing | |
| $71.36 | 7,100 | Director | 623,926 | 2018-03-29 | Filing | |
| $72.31 | 8,656 | Director | 631,026 | 2018-03-29 | Filing | |
| $73.26 | 9,044 | Director | 639,682 | 2018-03-29 | Filing | |
| $71.79 | 11,674 | Director | 15,329 | 2018-01-25 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 2,589,235 | $187,279 | 29.45% | |
| 2. | 244,540 | $17,688 | 2.18% | |
| 3. | 288,554 | $20,871 | 0.05% | |
| 4. | 30 | $2 | 0% | |
| 5. | 900 | $65 | 0% |
