| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 1,520,000 | $42,271 | 2.73% | |
| 2. | Iguana Healthcare Management Stuart Weisbrod | 100,000 | $2,781 | -20% | 1.81% |
| 3. | DAFNA Capital Management Nathan Fischel | 86,000 | $2,392 | +14% | 1.28% |
| 4. | Opaleye Management James A. Silverman | 100,000 | $2,781 | 0.89% | |
| 5. | 1,500,000 | $1,646 | 0.88% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $23.95 | 10,000 | 30,000 | 2017-08-14 | Filing | ||
| $22.57 | 20,000 | 20,000 | 2017-08-10 | Filing | ||
| $16.77 | 6,000 | Director | 6,000 | 2014-11-25 | Filing | |
| $16.00 | 1,292 | Large Shareholder, Director | 65,572 | 2014-10-08 | Filing | |
| $16.00 | 67,820 | Large Shareholder, Director | 3,441,075 | 2014-10-08 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $25.00 | 2,500 | 2,802 | 2018-03-02 | Filing | ||
| $25.85 | 600 | 29,682 | 2018-03-01 | Filing | ||
| $25.32 | 500 | 2,802 | 2018-03-01 | Filing | ||
| $28.55 | 3,000 | 2,802 | 2018-02-01 | Filing | ||
| $28.87 | 600 | 30,282 | 2018-02-01 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 95,000 | $759 | 0.09% | |
| 2. | 30,164 | $241 | 0.05% | |
| 3. | 902,700 | $7,212 | 0.04% | |
| 4. | 0 | $0 | 0% | |
| 5. | 250 | $2 | 0% |
