| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Renaissance Technologies Jim Simons | 5,261,628 | $457,498,555 | -8% | 0.63% |
| 2. | AQR Capital Management Cliff Asness | 2,582,561 | $224,553,662 | +536% | 0.08% |
| 3. | Tang Capital Management Kevin C. Tang | 1,500,000 | $130,425,000 | 5.92% | |
| 4. | D E Shaw D. E. Shaw | 883,001 | $76,776,937 | -26% | 0.04% |
| 5. | BioImpact Capital Mpm Capital | 771,028 | $67,040,885 | -22% | 4.09% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $33.56 | 24,218 | $812,836.00 | 1,146,631 | 2026-03-17 | Filing | |
| $33.00 | 75,782 | $2,500,972.72 | 1,122,413 | 2026-03-17 | Filing | |
| $21.53 | 100,000 | $2,153,000.00 | 3,308,303 | 2021-06-11 | Filing | |
| $21.53 | 50,000 | $1,076,500.00 | 1,046,838 | 2021-06-11 | Filing | |
| $22.64 | 68 | $1,539.52 | 3,208,303 | 2020-12-01 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $100.82 | 296 | $29,842.72 | 3,946 | 2026-09-16 | Filing | |
| $114.12 | 2,188 | $249,686.46 | 5,683 | 2026-09-14 | Filing | |
| $113.32 | 7,812 | $885,260.53 | 7,871 | 2026-09-14 | Filing | |
| $111.70 | 2,800 | $312,770.92 | 1,064,543 | 2026-09-15 | Filing | |
| $110.84 | 400 | $44,334.52 | 1,067,343 | 2026-09-15 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 12,432,023 | $1,080,964,444 | 0.02% | |
| 2. | 5,044,638 | $438,631,274 | 0.02% | |
| 3. | 4,172,482 | $362,797,310 | 0.01% | |
| 4. | 3,962,177 | $344,511,290 | 5.25% | |
| 5. | 3,337,618 | $290,205,885 | 0.01% |
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