| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Opaleye Management James A. Silverman | 1,200,000 | $5,280 | 1.34% | |
| 2. | Frazier Healthcare Partners Alan Frazier | 1,312,258 | $5,774 | 1.05% | |
| 3. | Aisling Capital Dennis Purcell | 1,021,148 | $4,493 | 0.97% | |
| 4. | Prosight Capital Lawrence Hawkins | 324,902 | $1,430 | -72% | 0.79% |
| 5. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,930,670 | $8,495 | 0.74% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $4.70 | 212,766 | Officer, Director | 268,320 | 2018-05-23 | Filing | |
| $7.57 | 60,000 | Large Shareholder | 2,295,272 | 2017-11-15 | Filing | |
| $6.79 | 7,350 | Officer, Director | 51,851 | 2017-09-12 | Filing | |
| $5.90 | 19,344 | Officer | 25,695 | 2017-06-07 | Filing | |
| $5.90 | 656 | Officer | 6,351 | 2017-06-06 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,356,813 | $3,189 | 4.47% | |
| 2. | 0 | $0 | 0% |
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