| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Sirios Capital Management John Brennan | 2,394,854 | $78,311 | -19% | 4.07% |
| 2. | OrbiMed Advisors Samuel Isaly | 9,574,695 | $313,093 | -8% | 3.73% |
| 3. | Sio Capital Michael Castor | 182,633 | $5,972 | -19% | 3.3% |
| 4. | Sivik Global Healthcare Krishen Sud | 260,000 | $8,502 | +49% | 3.26% |
| 5. | Valueworks LLC Charles Lemonides | 154,417 | $5,049 | -6% | 3.23% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $27.50 | 13 | Director | 32,337 | 2017-09-01 | Filing | |
| $27.80 | 30 | Director | 32,324 | 2017-06-16 | Filing | |
| $25.52 | 29 | Director | 32,294 | 2017-04-24 | Filing | |
| $16.49 | 30,000 | Director | 41,598 | 2016-02-12 | Filing | |
| $16.53 | 100,000 | Other | 500,000 | 2015-08-21 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $35.86 | 10,000 | Officer | 92,162 | 2018-09-10 | Filing | |
| $35.88 | 116,666 | Officer, Director | 2,023,104 | 2018-09-10 | Filing | |
| $35.86 | 10,000 | Officer | 34,636 | 2018-09-10 | Filing | |
| $36.02 | 5,000 | Officer | 24,201 | 2018-09-04 | Filing | |
| $34.87 | 72 | Director | 32,265 | 2018-08-15 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 2,757,666 | $90,176 | 39.15% | |
| 2. | 1,461,300 | $47,785 | 7.94% | |
| 3. | 435,330 | $14,235 | 4.82% | |
| 4. | 326,920 | $10,690 | 3.23% | |
| 5. | 608,585 | $19,901 | 2.9% |
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