| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 8,799,053 | $2,997,837,357 | 21.66% | |
| 2. | Hillhouse Capital Management Lei Zhang | 1,034,306 | $352,388,054 | 8.61% | |
| 3. | Siren L.L.C. Raymond Debbane | 492,990 | $167,961,693 | -4% | 6.57% |
| 4. | Marshall Wace LLP Paul Marshall And Ian Wace | 312,437 | $106,447,290 | -34% | 0.11% |
| 5. | GLG Partners Noam Gottesman | 209,016 | $71,211,751 | -15% | 0.12% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $302.06 | 165,529 | $49,999,938.03 | 18,943,802 | 2021-09-10 | Filing | |
| $108.00 | 5,231,900 | $565,045,200.00 | 5,250,491 | 2018-08-02 | Filing | |
| $108.00 | 582,200 | $62,877,600.00 | 600,791 | 2018-08-02 | Filing | |
| $101.00 | 1,645,148 | $166,159,948.00 | 5,121,404 | 2018-01-18 | Filing | |
| $101.00 | 335,050 | $33,840,050.00 | 708,025 | 2018-01-18 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $331.76 | 664 | $220,288.64 | 0 | 2026-01-07 | Filing | |
| $305.24 | 40 | $12,209.60 | 0 | 2025-12-16 | Filing | |
| $304.36 | 1,973 | $600,507.41 | 40 | 2025-12-16 | Filing | |
| $304.13 | 1,255 | $381,684.66 | 2,013 | 2025-12-16 | Filing | |
| $303.72 | 5,442 | $1,652,854.58 | 3,268 | 2025-12-16 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 2,957 | $898,366 | 0.18% | |
| 2. | 2,498 | $758,918 | 0.01% | |
| 3. | 1,756 | $533,490 | 1.18% | |
| 4. | 1,600 | $486,096 | 0.3% | |
| 5. | 1,408 | $427,764 | 0.01% |
