| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Baker Bros. Advisors Julian Baker And Felix Baker | 8,799,053 | $2,997,837,357 | 21.66% | |
| 2. | Hillhouse Capital Management Lei Zhang | 1,034,306 | $352,388,054 | 8.61% | |
| 3. | Siren L.L.C. Raymond Debbane | 492,990 | $167,961,693 | -4% | 6.57% |
| 4. | Marshall Wace LLP Paul Marshall And Ian Wace | 312,437 | $106,447,290 | -34% | 0.11% |
| 5. | GLG Partners Noam Gottesman | 209,016 | $71,211,751 | -15% | 0.12% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $302.06 | 165,529 | $49,999,938.03 | 18,943,802 | 2021-09-10 | Filing | |
| $108.00 | 5,231,900 | $565,045,200.00 | 5,250,491 | 2018-08-02 | Filing | |
| $108.00 | 582,200 | $62,877,600.00 | 600,791 | 2018-08-02 | Filing | |
| $101.00 | 1,645,148 | $166,159,948.00 | 5,121,404 | 2018-01-18 | Filing | |
| $101.00 | 335,050 | $33,840,050.00 | 708,025 | 2018-01-18 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $342.47 | 804 | $275,349.10 | 0 | 2025-11-26 | Filing | |
| $340.20 | 1,823 | $620,185.33 | 804 | 2025-11-26 | Filing | |
| $382.32 | 10 | $3,823.20 | 0 | 2025-11-17 | Filing | |
| $381.19 | 826 | $314,862.20 | 10 | 2025-11-17 | Filing | |
| $380.23 | 3,155 | $1,199,617.45 | 836 | 2025-11-17 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 5,080,461 | $1,730,913,063 | 1.33% | |
| 2. | 5,046,058 | $1,716,883,183 | 0.28% | |
| 3. | 3,784,935 | $1,289,527,366 | 0.07% | |
| 4. | 1,011,464 | $344,605,785 | 1.19% | |
| 5. | 496,090 | $169,017,922 | 0% |
