| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 2,404,853 | $54,398 | -19% | 5.44% |
| 2. | Prosight Capital Lawrence Hawkins | 275,941 | $6,242 | +131% | 3.22% |
| 3. | VenBio Select Advisor Kurt Von Emster | 1,000,000 | $22,620 | -5% | 1.35% |
| 4. | DAFNA Capital Management Nathan Fischel | 50,573 | $1,144 | +374% | 0.56% |
| 5. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 450,000 | $10,179 | -9% | 0.48% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $41.77 | 1,200 | Officer, Director | 669,291 | 2018-07-19 | Filing | |
| $41.19 | 1,200 | Officer, Director | 668,091 | 2018-07-19 | Filing | |
| $5.56 | 1,555 | Officer, Director | 634,391 | 2016-02-11 | Filing | |
| $5.52 | 8,445 | Officer, Director | 632,836 | 2016-02-10 | Filing | |
| $0.92 | 13,000 | Officer, Director | 58,000 | 2014-05-27 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $40.01 | 336 | Officer | 613,611 | 2018-09-06 | Filing | |
| $40.09 | 15,204 | Officer | 613,947 | 2018-09-05 | Filing | |
| $38.50 | 1,000 | Director | 19,465 | 2018-07-02 | Filing | |
| $42.47 | 1,000 | Director | 19,465 | 2018-06-01 | Filing | |
| $43.06 | 1,000 | Director | 19,465 | 2018-05-01 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 718,500 | $16,252 | 12.39% | |
| 2. | 686,644 | $15,532 | 1.42% | |
| 3. | 68,875 | $1,524 | 0.65% | |
| 4. | 200,000 | $4,524 | 0.63% | |
| 5. | 389,340 | $8,807 | 0.43% |
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