| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 2,943,165 | $144,627 | +1% | 14.5% |
| 2. | VenBio Select Advisor Kurt Von Emster | 1,093,934 | $53,756 | +3% | 2.56% |
| 3. | Lyon Street Capital Brian C. Freckmann | 138,725 | $6,817 | +11% | 2.19% |
| 4. | Ghost Tree Capital Ken Greenberg And David Kim | 150,000 | $7,371 | 1.49% | |
| 5. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 443,000 | $21,769 | -2% | 0.92% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $5.56 | 1,555 | Officer, Director | 634,391 | 2016-02-11 | Filing | |
| $5.52 | 8,445 | Officer, Director | 632,836 | 2016-02-10 | Filing | |
| $0.92 | 13,000 | Officer, Director | 58,000 | 2014-05-27 | Filing | |
| $0.91 | 15,000 | Officer, Director | 45,000 | 2014-05-23 | Filing | |
| $0.90 | 5,000 | Officer, Director | 30,000 | 2014-05-22 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $42.47 | 1,000 | Director | 19,465 | 2018-06-01 | Filing | |
| $43.06 | 1,000 | Director | 19,465 | 2018-05-01 | Filing | |
| $49.32 | 1,000 | Director | 19,465 | 2018-04-02 | Filing | |
| $56.37 | 1,000 | Director | 19,465 | 2018-03-01 | Filing | |
| $46.86 | 1,000 | Director | 19,465 | 2018-02-01 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,115,000 | $54,791 | 8.94% | |
| 2. | 155,000 | $7,617 | 1.24% | |
| 3. | 31,863 | $1,566 | 0.64% | |
| 4. | 23,941 | $1,176 | 0.6% | |
| 5. | 19,502 | $912 | 0.34% |
