| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 2,943,164 | $133,178 | 14.99% | |
| 2. | VenBio Select Advisor Kurt Von Emster | 1,068,534 | $48,351 | +18% | 3.13% |
| 3. | Lyon Street Capital Brian C. Freckmann | 125,443 | $5,676 | -17% | 1.89% |
| 4. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 450,000 | $20,363 | +16% | 0.92% |
| 5. | Perceptive Advisors Joseph Edelman | 536,626 | $24,282 | +22% | 0.8% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $5.56 | 1,555 | Officer, Director | 634,391 | 2016-02-11 | Filing | |
| $5.52 | 8,445 | Officer, Director | 632,836 | 2016-02-10 | Filing | |
| $0.92 | 13,000 | Officer, Director | 58,000 | 2014-05-27 | Filing | |
| $0.91 | 15,000 | Officer, Director | 45,000 | 2014-05-23 | Filing | |
| $0.90 | 5,000 | Officer, Director | 30,000 | 2014-05-22 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $49.32 | 1,000 | Director | 19,465 | 2018-04-02 | Filing | |
| $56.37 | 1,000 | Director | 19,465 | 2018-03-01 | Filing | |
| $46.86 | 1,000 | Director | 19,465 | 2018-02-01 | Filing | |
| $45.04 | 1,000 | Director | 19,465 | 2018-01-02 | Filing | |
| $49.37 | 1,000 | Director | 19,465 | 2017-12-01 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 31,863 | $1,566 | 0.64% | |
| 2. | 17,096 | $840 | 0.33% | |
| 3. | 650 | $32 | 0% |
