| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 2,943,164 | $115,401 | -1% | 10.98% |
| 2. | Ghost Tree Capital Ken Greenberg And David Kim | 235,000 | $9,214 | +57% | 2.71% |
| 3. | Lyon Street Capital Brian C. Freckmann | 150,144 | $5,887 | +9% | 2.09% |
| 4. | VenBio Select Advisor Kurt Von Emster | 963,427 | $37,776 | -12% | 1.45% |
| 5. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 450,000 | $17,645 | +2% | 0.67% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $41.77 | 1,200 | Officer, Director | 669,291 | 2018-07-19 | Filing | |
| $41.19 | 1,200 | Officer, Director | 668,091 | 2018-07-19 | Filing | |
| $5.56 | 1,555 | Officer, Director | 634,391 | 2016-02-11 | Filing | |
| $5.52 | 8,445 | Officer, Director | 632,836 | 2016-02-10 | Filing | |
| $0.92 | 13,000 | Officer, Director | 58,000 | 2014-05-27 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $38.50 | 1,000 | Director | 19,465 | 2018-07-02 | Filing | |
| $42.47 | 1,000 | Director | 19,465 | 2018-06-01 | Filing | |
| $43.06 | 1,000 | Director | 19,465 | 2018-05-01 | Filing | |
| $49.32 | 1,000 | Director | 19,465 | 2018-04-02 | Filing | |
| $56.37 | 1,000 | Director | 19,465 | 2018-03-01 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,162,000 | $45,562 | 8.11% | |
| 2. | 65,301 | $2,560 | 1.87% | |
| 3. | 147,500 | $5,783 | 1.02% | |
| 4. | 40,682 | $1,598 | 0.59% | |
| 5. | 233,387 | $9,151 | 0.34% |
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