9. Paraguayan Guarani (PYG)
1 USD = 5,562.89 PYG
Just like in Cambodia, the centavo coins are no longer in use in Paraguay due to high inflation. At 5,562.89 PYG against one US dollar, the Paraguayan Guarani is the weakest currency in the Americas. According to Trading Economics, it reached its record low of 3,642.70 in August 2011.