| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Copernicus Capital Management John W. Rende | 52,453 | $12,481 | -10% | 15.1% |
| 2. | Parkman Healthcare Partners Greg Martinez | 42,842 | $10,194 | -6% | 4.72% |
| 3. | Rhenman & Partners Asset Management Henrik Rhenman | 115,000 | $27,364 | -29% | 3.83% |
| 4. | Logos Capital Arsani William | 33,237 | $7,909 | 3% | |
| 5. | OrbiMed Advisors Samuel Isaly | 737,400 | $175,464 | -6% | 2.94% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $51.23 | 15 | Director | 1,088 | 2012-08-10 | Filing | |
| $29.19 | 9 | Director | 1,088 | 2011-12-07 | Filing | |
| $29.66 | 33 | Director | 1,088 | 2011-12-06 | Filing | |
| $28.00 | 31 | Director | 1,088 | 2011-11-22 | Filing | |
| $45.50 | 1,000 | Director | 1,000 | 2012-11-07 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $288.37 | 9 | Officer, Director | 26,626 | 2020-05-15 | Filing | |
| $287.63 | 19 | Officer, Director | 26,635 | 2020-05-15 | Filing | |
| $286.07 | 27 | Officer, Director | 26,654 | 2020-05-15 | Filing | |
| $283.76 | 10 | Officer, Director | 26,681 | 2020-05-15 | Filing | |
| $282.74 | 4 | Officer, Director | 26,691 | 2020-05-15 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 77,822 | $18,517 | 8.44% | |
| 2. | 13,734 | $3,268 | 6.76% | |
| 3. | 1,273,089 | $302,932 | 5.87% | |
| 4. | 485,730 | $115,579 | 5.22% | |
| 5. | 65,118 | $15,495 | 5.13% |
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