| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Copernicus Capital Management John W. Rende | 17,863 | $3,286 | -46% | 8.42% |
| 2. | Chiron Investment Management Ryan Caldwell | 136,907 | $25,184 | 4.55% | |
| 3. | Ghost Tree Capital Ken Greenberg And David Kim | 80,000 | $14,716 | 3.98% | |
| 4. | OrbiMed Advisors Samuel Isaly | 955,300 | $175,727 | -16% | 2.72% |
| 5. | Healthcor Management LP Arthur B Cohen And Joseph Healey | 338,770 | $62,317 | +76% | 2.51% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $51.23 | 15 | Director | 1,088 | 2012-08-10 | Filing | |
| $29.19 | 9 | Director | 1,088 | 2011-12-07 | Filing | |
| $29.66 | 33 | Director | 1,088 | 2011-12-06 | Filing | |
| $28.00 | 31 | Director | 1,088 | 2011-11-22 | Filing | |
| $45.50 | 1,000 | Director | 1,000 | 2012-11-07 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $181.89 | 2,125 | Officer | 33,240 | 2019-06-19 | Filing | |
| $176.11 | 4,249 | Officer, Director | 106,287 | 2019-06-18 | Filing | |
| $175.33 | 51,781 | Officer, Director | 110,536 | 2019-06-18 | Filing | |
| $167.78 | 320 | Director | 6,540 | 2019-06-03 | Filing | |
| $166.52 | 400 | Director | 6,860 | 2019-06-03 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,300,000 | $239,135 | 6.01% | |
| 2. | 51,122 | $9,400 | 3.47% | |
| 3. | 443,712 | $81,621 | 3.31% | |
| 4. | 22,832 | $4,310 | 3% | |
| 5. | 54,950 | $10,108 | 2.53% |
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