| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Copernicus Capital Management John W. Rende | 62,907 | $12,125 | -6% | 11.38% |
| 2. | Eversept Partners Kamran Moghtaderi | 48,092 | $9,269 | +39% | 4.46% |
| 3. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 8,727 | $1,682 | -7% | 4.01% |
| 4. | OrbiMed Advisors Samuel Isaly | 1,600,500 | $308,480 | -11% | 3.71% |
| 5. | Sivik Global Healthcare Krishen Sud | 35,000 | $6,746 | -20% | 2.4% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $51.23 | 15 | Director | 1,088 | 2012-08-10 | Filing | |
| $29.19 | 9 | Director | 1,088 | 2011-12-07 | Filing | |
| $29.66 | 33 | Director | 1,088 | 2011-12-06 | Filing | |
| $28.00 | 31 | Director | 1,088 | 2011-11-22 | Filing | |
| $45.50 | 1,000 | Director | 1,000 | 2012-11-07 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $186.52 | 809 | Officer | 16,087 | 2018-12-03 | Filing | |
| $163.75 | 12 | Officer | 16,087 | 2018-11-15 | Filing | |
| $163.75 | 90 | Officer | 39,609 | 2018-11-15 | Filing | |
| $163.75 | 61 | Officer | 46,662 | 2018-11-15 | Filing | |
| $163.75 | 29 | Officer | 46,752 | 2018-11-15 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,370,445 | $264,140 | 6.98% | |
| 2. | 67,722 | $10,009 | 4.75% | |
| 3. | 408,235 | $78,683 | 2.85% | |
| 4. | 142,465 | $27,459 | 2.75% | |
| 5. | 19,123 | $3,686 | 2.47% |
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