| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 1,792,600 | $304,670 | -4% | 3.63% |
| 2. | Opus Point Partners Management Michael S. Weiss And Lindsay A. Rosenwald | 9,331 | $1,586 | +2% | 3.43% |
| 3. | Sivik Global Healthcare Krishen Sud | 43,600 | $7,410 | +25% | 2.84% |
| 4. | Brookside Capital Bain Capital | 241,408 | $41,030 | +168% | 2.76% |
| 5. | Pura Vida Investments Efrem Kamen | 15,000 | $2,549 | 2.15% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $51.23 | 15 | Director | 1,088 | 2012-08-10 | Filing | |
| $29.19 | 9 | Director | 1,088 | 2011-12-07 | Filing | |
| $29.66 | 33 | Director | 1,088 | 2011-12-06 | Filing | |
| $28.00 | 31 | Director | 1,088 | 2011-11-22 | Filing | |
| $45.50 | 1,000 | Director | 1,000 | 2012-11-07 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $181.89 | 2,125 | Officer | 39,113 | 2018-08-28 | Filing | |
| $174.20 | 2,330 | Officer | 39,609 | 2018-08-03 | Filing | |
| $176.69 | 100 | Officer | 46,662 | 2018-08-03 | Filing | |
| $175.86 | 700 | Officer | 46,762 | 2018-08-03 | Filing | |
| $174.50 | 1,142 | Officer | 47,462 | 2018-08-03 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 53,208 | $9,043 | 8.89% | |
| 2. | 66,440 | $11,292 | 8.19% | |
| 3. | 83,222 | $14,144 | 5.43% | |
| 4. | 17,630 | $2,996 | 4.78% | |
| 5. | 581,522 | $98,835 | 3.75% |
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