| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Consonance Capital Management Mitchell Blutt | 4,609,043 | $87,802 | +51% | 5.66% |
| 2. | Palo Alto Investors William Leland Edwards | 4,155,670 | $79,166 | 3.16% | |
| 3. | Armistice Capital Steven Boyd | 2,224,000 | $42,367 | -15% | 2.76% |
| 4. | VenBio Select Advisor Kurt Von Emster | 2,800,191 | $53,344 | +1% | 2.05% |
| 5. | Cormorant Asset Management Bihua Chen | 957,821 | $18,246 | 1.35% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $8.97 | 3,239 | Large Shareholder, Other | 1,103,617 | 2015-12-16 | Filing | |
| $8.97 | 4,441 | Large Shareholder, Other | 2,740,122 | 2015-12-16 | Filing | |
| $8.97 | 3,490 | Large Shareholder, Other | 2,152,952 | 2015-12-16 | Filing | |
| $8.61 | 93,634 | Large Shareholder, Other | 1,100,378 | 2015-12-11 | Filing | |
| $8.61 | 128,374 | Large Shareholder, Other | 2,735,681 | 2015-12-11 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $18.72 | 60,966 | Officer, Director | 1,182,872 | 2018-03-01 | Filing | |
| $18.72 | 8,532 | Officer | 199,534 | 2018-03-01 | Filing | |
| $18.71 | 3,660 | Officer | 115,073 | 2018-03-01 | Filing | |
| $18.72 | 8,525 | Officer | 139,841 | 2018-03-01 | Filing | |
| $15.30 | 21,535 | Officer, Director | 1,183,838 | 2018-01-02 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 825,375 | $18,942 | 0.1% | |
| 2. | 50,182 | $1,152 | 0.04% | |
| 3. | 23,200 | $532 | 0.02% | |
| 4. | 5,000 | $115 | 0.01% | |
| 5. | 291 | $7 | 0% |
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