| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | DAFNA Capital Management Nathan Fischel | 13,680,554 | $48,019 | 18.05% | |
| 2. | Opaleye Management James A. Silverman | 4,070,000 | $14,286 | 5.16% | |
| 3. | Arbiter Partners Capital Management Paul J. Isaac | 4,677,385 | $16,418 | 2.98% | |
| 4. | Redmile Group Jeremy Green | 3,285,000 | $11,530 | 0.38% | |
| 5. | GMT Capital Thomas E. Claugus | 126,581 | $444 | 0.01% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $1.95 | 3,000 | Director | 42,290 | 2015-03-13 | Filing | |
| $1.45 | 10,000 | Officer, Director | 239,711 | 2014-12-12 | Filing | |
| $1.43 | 10,000 | Officer, Director | 229,711 | 2014-12-05 | Filing | |
| $2.75 | 10,000 | Officer, Director | 219,711 | 2014-08-11 | Filing | |
| $1.53 | 24,360 | Director | 76,072 | 2012-11-30 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $1.44 | 760 | Director | 157,954 | 2018-11-28 | Filing | |
| $1.57 | 26,064 | Director | 1,107,189 | 2015-06-15 | Filing | |
| $1.60 | 1,116 | Director | 1,133,253 | 2015-06-12 | Filing | |
| $1.61 | 11,703 | Director | 1,134,369 | 2015-06-11 | Filing | |
| $1.60 | 3,454 | Director | 1,146,072 | 2015-06-10 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 0 | $0 | 0% | |
| 2. | 10,155 | $53 | 0% |
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