| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Deerfield Management James E. Flynn | 1,526,000 | $28,078 | -18% | 1% |
| 2. | OrbiMed Advisors Samuel Isaly | 1,034,711 | $19,039 | -80% | 0.22% |
| 3. | Sivik Global Healthcare Krishen Sud | 30,000 | $552 | 0.19% | |
| 4. | Point72 Asset Management Steve Cohen | 1,728,700 | $31,808 | +252% | 0.13% |
| 5. | PAR Capital Management Paul Reeder And Edward Shapiro | 617,408 | $11,360 | 0.13% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $12.32 | 8,100 | Director | 164,334 | 2015-09-10 | Filing | |
| $14.00 | 100,000 | Large Shareholder | 13,950,000 | 2014-08-11 | Filing | |
| $10.00 | 10,000 | Officer, Director | 10,000 | 2009-09-30 | Filing | |
| $10.00 | 20,000 | Officer | 284,028 | 2009-09-30 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $20.00 | 640 | Officer, Director | 7,189,823 | 2018-11-09 | Filing | |
| $20.00 | 25,274 | Officer, Director | 7,190,463 | 2018-11-08 | Filing | |
| $20.09 | 35,834 | Officer, Director | 7,215,737 | 2018-11-07 | Filing | |
| $20.05 | 37,468 | Officer, Director | 7,251,571 | 2018-11-06 | Filing | |
| $20.00 | 9,000 | Director | 95,865 | 2018-11-06 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 16,029 | $246 | 0.13% | |
| 2. | 0 | $0 | 0% | |
| 3. | 434 | $666 | 0% | |
| 4. | 0 | $0 | 0% | |
| 5. | 41 | $1 | 0% |
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