| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Ghost Tree Capital Ken Greenberg And David Kim | 210,000 | $33,917 | +20% | 7.22% |
| 2. | VenBio Select Advisor Kurt Von Emster | 943,500 | $152,385 | -2% | 6.99% |
| 3. | 1,746 | $28,200 | -18% | 3.6% | |
| 4. | Eversept Partners Kamran Moghtaderi | 42,194 | $6,815 | +6% | 3.28% |
| 5. | Cadian Capital Eric Bannasch | 387,600 | $62,601 | +39% | 2.84% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $120.94 | 3,134 | Officer, Director | 415,945 | 2018-10-30 | Filing | |
| $120.26 | 13,561 | Officer, Director | 412,811 | 2018-10-30 | Filing | |
| $125.26 | 16,000 | Officer, Director | 399,250 | 2018-08-15 | Filing | |
| $52.44 | 38,138 | Officer, Director | 420,196 | 2017-11-08 | Filing | |
| $42.50 | 47,058 | Officer, Director | 382,058 | 2017-07-27 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $140.50 | 6,667 | Director | 10,084 | 2018-11-01 | Filing | |
| $131.71 | 10,000 | Director | 116,534 | 2018-10-31 | Filing | |
| $127.74 | 107,524 | Officer | 20,661 | 2018-10-24 | Filing | |
| $136.46 | 37,848 | Officer | 34,871 | 2018-07-16 | Filing | |
| $136.46 | 9,056 | Officer | 34,871 | 2018-07-16 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 44,113,000 | $102,074 | 6.11% | |
| 2. | 620,000 | $100,136 | 3.67% | |
| 3. | 314,070 | $50,725 | 3.03% | |
| 4. | 53,223 | $8,596 | 2.41% | |
| 5. | 14,508 | $2,343 | 2.16% |
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