| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Ghost Tree Capital Ken Greenberg And David Kim | 175,000 | $23,132 | -26% | 6.8% |
| 2. | VenBio Select Advisor Kurt Von Emster | 958,928 | $126,751 | 4.87% | |
| 3. | 2,117 | $27,983 | -10% | 4.32% | |
| 4. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 205,699 | $27,189 | -38% | 3.03% |
| 5. | 908 | $12,002 | +3% | 1.85% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $125.26 | 16,000 | Officer, Director | 399,250 | 2018-08-15 | Filing | |
| $52.44 | 38,138 | Officer, Director | 420,196 | 2017-11-08 | Filing | |
| $42.50 | 47,058 | Officer, Director | 382,058 | 2017-07-27 | Filing | |
| $14.54 | 10,000 | Director | 21,855 | 2016-03-16 | Filing | |
| $16.54 | 65,000 | Director | 112,166 | 2016-03-14 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $136.46 | 37,848 | Officer | 34,871 | 2018-07-16 | Filing | |
| $136.46 | 9,056 | Officer | 34,871 | 2018-07-16 | Filing | |
| $136.46 | 3,096 | Officer | 34,871 | 2018-07-16 | Filing | |
| $137.32 | 11,914 | Officer | 28,766 | 2018-07-09 | Filing | |
| $137.32 | 9,944 | Officer | 28,766 | 2018-07-09 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 978,551 | $129,345 | 9.32% | |
| 2. | 375,000 | $49,568 | 5.61% | |
| 3. | 32,500,000 | $63,101 | 3.77% | |
| 4. | 145,096 | $19,179 | 2.64% | |
| 5. | 40,000 | $5,287 | 2.52% |
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