| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 3,135,000 | $244,906 | +1% | 4.47% |
| 2. | EcoR1 Capital Oleg Nodelman | 2,069,634 | $161,680 | 5.05% | |
| 3. | Deerfield Management James E. Flynn | 88,657,000 | $116,124 | 2.59% | |
| 4. | 87,499,000 | $115,167 | +7% | 3.58% | |
| 5. | Point72 Asset Management Steve Cohen | 1,447,211 | $113,056 | +26% | 0.44% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $79.33 | 3,780 | Officer | 65,678 | 2021-11-24 | Filing | |
| $79.94 | 25,026 | Officer, Director | 365,082 | 2021-11-17 | Filing | |
| $87.49 | 3,309 | Director | 3,187,065 | 2019-09-13 | Filing | |
| $87.49 | 1,691 | Director | 3,183,756 | 2019-09-12 | Filing | |
| $86.74 | 2,000 | Director | 7,051 | 2019-09-09 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $85.76 | 5,000 | Director | 130,517 | 2021-03-10 | Filing | |
| $83.51 | 10,000 | Director | 16,518 | 2021-03-08 | Filing | |
| $165.00 | 1,115 | Officer | 8,140 | 2020-12-11 | Filing | |
| $160.00 | 1,125 | Officer | 8,140 | 2020-12-08 | Filing | |
| $159.65 | 777 | Director | 13,792 | 2020-08-10 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 137,545 | $10,745,014 | 0% | |
| 2. | 130,953 | $10,230,048 | 0.01% | |
| 3. | 35,883 | $2,803,179 | 0.02% | |
| 4. | 1,337,000 | $1,755,225 | 0% | |
| 5. | 8,315,182 | $649,582 | 0.01% |
