| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | VenBio Select Advisor Kurt Von Emster | 4,627,888 | $529,985,734 | +27% | 7.18% |
| 2. | EcoR1 Capital Oleg Nodelman | 3,660,798 | $419,234,587 | +23% | 10.27% |
| 3. | Two Sigma Advisors John Overdeck And David Siegel | 1,259,434 | $144,230,382 | +8% | 0.36% |
| 4. | Farallon Capital Thomas Steyer | 1,205,200 | $138,019,504 | +32% | 0.77% |
| 5. | Casdin Capital Eli Casdin | 1,015,000 | $116,237,800 | -13% | 10.15% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $109.89 | 4,032 | Director | 246,996 | 2023-08-14 | Filing | |
| $109.19 | 5,947 | Director | 242,964 | 2023-08-14 | Filing | |
| $108.05 | 23,686 | Director | 237,017 | 2023-08-11 | Filing | |
| $106.26 | 31,570 | Director | 213,331 | 2023-08-10 | Filing | |
| $105.90 | 1,091 | Director | 181,761 | 2023-08-10 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $106.72 | 15,000 | Director | 20,994 | 2023-08-04 | Filing | |
| $109.92 | 858 | Director | 6,387 | 2022-11-17 | Filing | |
| $85.76 | 5,000 | Director | 130,517 | 2021-03-10 | Filing | |
| $83.51 | 10,000 | Director | 16,518 | 2021-03-08 | Filing | |
| $165.00 | 1,115 | Officer | 8,140 | 2020-12-11 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 8,531,479 | $977,024,976 | 0.02% | |
| 2. | 5,503,466 | $630,256,925 | 0.01% | |
| 3. | 5,447,667 | $623,869,537 | 0.38% | |
| 4. | 3,855,102 | $441,486,282 | 0.08% | |
| 5. | 2,432,768 | $278,600,645 | 0.05% |
