| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Great Point Partners Jeffrey Jay And David Kroin | 8,579,454 | $30,371,000 | +9% | 4.51% |
| 2. | Pura Vida Investments Efrem Kamen | 584,563 | $2,069,353 | -4% | 1.73% |
| 3. | DAFNA Capital Management Nathan Fischel | 901,933 | $3,193 | -9% | 1.55% |
| 4. | Palo Alto Investors William Leland Edwards | 3,966,087 | $14,040 | +1% | 0.6% |
| 5. | Rock Springs Capital Management Kris Jenner, Gordon Bussard, Graham Mcphail | 2,575,000 | $9,116 | +5% | 0.38% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.47 | 8,102 | Large Shareholder | 799,615 | 2013-06-07 | Filing | |
| $3.47 | 24,598 | Large Shareholder | 1,455,414 | 2013-06-07 | Filing | |
| $8.00 | 301,424 | Large Shareholder, Other | 3,204,167 | 2011-05-26 | Filing | |
| $8.00 | 229,252 | Large Shareholder, Other | 2,279,997 | 2011-05-26 | Filing | |
| $8.00 | 72,800 | Large Shareholder, Other | 762,700 | 2011-05-26 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $4.11 | 5,000 | Officer | 0 | 2018-04-20 | Filing | |
| $3.90 | 100,000 | Officer | 0 | 2017-11-03 | Filing | |
| $2.69 | 5,000 | Officer | 0 | 2017-07-05 | Filing | |
| $2.41 | 5,000 | Officer | 0 | 2017-01-03 | Filing | |
| $4.00 | 5,303 | Officer, Director | 53,031 | 2016-08-30 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 5,140,000 | $18,196 | 1.94% | |
| 2. | 1,617,769 | $5,727 | 0.7% | |
| 3. | 212,882 | $754 | 0.65% | |
| 4. | 3,243,150 | $11,481 | 0.51% | |
| 5. | 370,000 | $1,302 | 0.5% |
