| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Great Point Partners Jeffrey Jay And David Kroin | 7,888,581 | $30,608 | -14% | 5.22% |
| 2. | DAFNA Capital Management Nathan Fischel | 983,478 | $3,816 | +122% | 2.05% |
| 3. | Sio Capital Michael Castor | 885,055 | $3,434 | -44% | 1.93% |
| 4. | Pura Vida Investments Efrem Kamen | 604,563 | $2,345,704 | 1.73% | |
| 5. | Ghost Tree Capital Ken Greenberg And David Kim | 825,000 | $3,201 | -25% | 0.75% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.47 | 8,102 | Large Shareholder | 799,615 | 2013-06-07 | Filing | |
| $3.47 | 24,598 | Large Shareholder | 1,455,414 | 2013-06-07 | Filing | |
| $8.00 | 301,424 | Large Shareholder, Other | 3,204,167 | 2011-05-26 | Filing | |
| $8.00 | 229,252 | Large Shareholder, Other | 2,279,997 | 2011-05-26 | Filing | |
| $8.00 | 72,800 | Large Shareholder, Other | 762,700 | 2011-05-26 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $3.90 | 100,000 | Officer | 0 | 2017-11-03 | Filing | |
| $2.69 | 5,000 | Officer | 0 | 2017-07-05 | Filing | |
| $2.41 | 5,000 | Officer | 0 | 2017-01-03 | Filing | |
| $4.00 | 5,303 | Officer, Director | 53,031 | 2016-08-30 | Filing | |
| $3.68 | 41,666 | Officer, Director | 58,334 | 2015-06-10 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,617,769 | $5,727 | 0.7% | |
| 2. | 0 | $0 | 0% | |
| 3. | 27 | $0 | 0% | |
| 4. | 10,000 | $35 | 0% | |
| 5. | 720 | $2 | 0% |
